geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Multiplex flow assays preferably with magnetic particles as solid phase


, : Multiplex flow assays preferably with magnetic particles as solid phase. Official Gazette of the United States Patent & Trademark Office Patents 1249(4), Aug 28

Heterogeneous assays for different analytes in a single biological sample are performed simultaneously in a multiplexed assay that combines flow cytometry with the use of magnetic particles as the solid phase and yields an individual result for each analyte. The particles are distinguishable from each other by characteristics that permit them to be differentiated into groups, each group carrying an assay reagent bonded to the particle surface that is distinct from the assay reagents of particles in other groups. The magnetic particles facilitate separation of the solid and liquid phases, permitting the assays to be performed by automated equipment. Assays are also disclosed for the simultaneous detection of antibodies of different classes and a common antigen specificity or of a common class and different antigen specificities. Each type is accomplished by immunological binding at the surfaces of two distinct solid phases in a sequential manner with dissociation of the binding and washing of the solid phase in between the binding steps.

US$29.90


Other references

Cheyne, E.; Everett, J.; Cavan, D.; Kerr, D., 2000: Making sense of type 1 diabetes Unrecognised hypoglyceamia during continuous glucose sensing. Diabetologia 43(Supplement 1): A206, August

Block, J.J., 2007: Lack of association between video game exposure and school performance. Pediatrics 119(2): 413; Author Reply 413-4

Galdston, I., 2010: The status of health education in industry. Occupational Medicine 1: 471-474

Hagiwara H.; Shibasaki S.; Ohwada N., 1990: Abnormal cilia in human uterine tube epithelium. Abnormal cilia were studied in human uterine tube epithelum under the physiological conditions, using both transmission and scanning electron microscopes. Ciliary abnormalities were recognized in 13 out of 20 cases examined and fell into the follo...

Durand, J.M.; Cretel, E.; Kaplanski, G.; Lefevre, P.; Retornaz, F.; Soubeyrand, J., 1994: Long-term results of therapy with interferon alpha for cryoglobulinemia associated with hepatitis C virus infection. We describe the long term results of treatment with interferon (IFN) in two patients with cryoglobulinemia and chronic hepatitis related to Hepatitis C virus (HCV). Our results suggest that interferon may induce long remission in cryoglobulinemia...

Tojo, N.; Hayashi, A.; Miyakoshi, A., 2015: Corneal decompensation following filtering surgery with the Ex-PRESS(®) mini glaucoma shunt device. To report a case of corneal decompensation due to the Ex-PRESS(®) mini glaucoma shunt device (Ex-PRESS). A 75-year-old man had pseudoexfoliation glaucoma in his right eye. He underwent filtration surgery with Ex-PRESS. His intraocular pressure wa...

Zippel, H.H.; Schulz, K.D.; Del Pozo, E., 1977: Morphological studies on proliferating breast changes under the influence of prolactin inhibiting drugs (proceedings). Archiv für Gynakologie 224(1-4): 338-339

Orti Cabo F.; Pueyo Mur Juan J., 1980: Diagenetic polyhalite in a continental evaporitic sequence, Miocene, Tagus Basin, Spain. Revista del Instituto de Investigaciones Geologicas de la Diputacion Provincial de Barcelona 34: 209-222

Kohanski, R.A.; Bishop, S.M.; Ross, J.B.A., 1999: Autophosphorylation dependent destabilization of the insulin receptor kinase domain. Biophysical Journal 76(1 PART 2): A150, Jan

Wyatt, P.J., 1969: Identification of bacteria by differential light scattering. Nature 221(5187): 1257-1258