geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Opioids and immunosuppression. Clinical relevance?


, : Opioids and immunosuppression. Clinical relevance?. Der Anaesthesist 52(5): 442-452

First observations that opioids may have disadvantageous effects on the immune response have been made more than 100 years ago. Today the immunosuppressive effect of morphine is well established. Drug-induced immunomodulation is of growing importance in modern anesthetic concepts. The reduced stress response observed after morphine application contributes to this effect as well as direct impairment of immune effector cells such as bactericidal activity, intracellular killing, proliferative response or cytokine synthesis. Opioid-induced immunomodulation is mediated by opioid receptors found on immunocytes and in the central nervous system. A negative feedback mechanism via the hypothalamo-pituitary-adrenal axis may potentiate the direct inhibitory effect of morphine on the immune response. A final statement regarding the clinical relevance of opioid-induced immunosuppression cannot be made at this point, since the existing clinical data are preliminary and inconclusive. Therefore, further clinical studies are mandatory to elucidate the influence of opioid treatment on immune regulation in different clinical settings in anesthesia, critical care, pain therapy and emergency medicine. Further investigations may help to not only provide sufficient analgesia by application of opioids, but also to assess advantages and disadvantages on immune function.

US$19.90

PMID: 12750829

DOI: 10.1007/s00101-003-0506-y


Other references

Anonymous, 1995: The French and drug information. Revue de L'infirmiere: 61-61

Villanueva Anadón, B.; Claramonte Delaviuda, M.; Zalba Etayo, B.; Obón Azuara, B., 2006: Ventriculitis due to Haemophilus aphrophilus in a 21 year old patient and right-left shunt. Medicina Intensiva 30(7): 344-344

Bacskulin, A.; Eckardt, E., 1993: Pars plana-vitrectomy in the treatment of chronic uveitis in childhood. During 1986-1991 vitreous surgery was performed in 5 girls and 8 boys (age range 2-15 years) with chronic uveitis. In 6 cases a combined lensectomy-vitrectomy was performed because cataract was present, so that the results generally refer to 19 ey...

Krügel, K.; Wurm, A.; Pannicke, T.; Hollborn, M.; Karl, A.; Wiedemann, P.; Reichenbach, A.; Kohen, L.; Bringmann, A., 2011: Involvement of oxidative stress and mitochondrial dysfunction in the osmotic swelling of retinal glial cells from diabetic rats. Osmotic swelling of retinal glial (Müller) cells may contribute to the development of edema in diabetic retinopathy. Here, we tested whether oxidative stress and mitochondrial dysfunction are pathogenic factors involved in the osmotic swelling of...

Tartaglione T.A.; Taylor T.O.; Opheim K.E.; See W.A.; Berger R.E., 1991: Antimicrobial tissue penetration in a rat model of escherichia coli epididymitis. Following induction of unilateral epididymitis by intratesticular injection of E. coli, a single intraperitoneal dose of amdinocillin, ampicillin, doxycycline, tobramycin, or trimethoprim/sulfamethoxazole was administered to five groups of rats. T...

Persson, R., 1977: Forest resources of Africa: an approach to international forest resource appraisals. iI. regional analyses. 22

Vladeck, B.C., 1981: The market vs. regulation: the case for regulation. Milbank Memorial Fund Quarterly. Health and Society 59(2): 209-223

Angel, S.B.sker, D.K.nner, J.J.ven, B., 1981: Assessment of shelf life of fresh water prawns stored at 0 degrees C. Journal of food technology 16(4): 357-366

Okulewicz, J., 1989: Breeding biology and ecology of the reed bunting Emberiza schoeniclus in the region of the Milicz fish-pond area. Ptaki Slaska, 7: 1-39

Yamada, S.; Tonomura, Y., 1972: Phosphorylation of the Ca 2+ -Mg 2+ -dependent ATPase of the sarcoplasmic reticulum coupled with cation translocation. Journal of Biochemistry 71(6): 1101-1104