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P2x7 purinergic receptors exist in the neuron in the monkey retina


, : P2x7 purinergic receptors exist in the neuron in the monkey retina. Society for Neuroscience Abstract Viewer & Itinerary Planner : Abstract No 843 5

P2X7 purinoceptors are expressed mostly in glia cells and considered to work as a trigger of cytolysis in the brain. In the rodent retina, however, P2X7 is expressed in several classes of neurons including ganglion cells. In the present study we identified immunopositive cells for P2X7 in the monkey retina by double immunolabeling. The immunohistochemical distribution of other purinoceptor subtypes (P2X1, P2X2 and P2X4) was also examined. Immunoreactivity for P2X7 was observed in the inner nuclear layer (INL), the inner plexiform layer (IPL), and the ganglion cell layer (GCL). In the INL, strongly immunopositive cells corresponded to the subpopulation of horizontal cells which was labeled by the calcium binding proteins, parvalbumin, calretinin and calbindin-D. In the IPL, fine processes were immunopositive. In the GCL, most of the ganglion cells showed P2X7 immunoreactivity, with simultaneous expression of parvalbumin and calbindin-D, but not calretinin. No P2X7 immunoreactivity was found in non-neural cells, i.e. Muller cells or microglia. Immunoreactivity for P2X1 was strongly evident in a band, in sublamina a of the IPL. The band existed at almost the same level as tyrosine hydroxylase immunoreactivity, but did not seem to actually overlap with this. P2X2 was not expressed in the retina, and P2X4, only faintly expressed, at the scleral margin of the INL. Since P2X7 in the primate retina is expressed exclusively in neurons, it may in this location be involved in neural transmission rather than in cytolysis, as found for glia cells.

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