+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

P2y2 nucleotide receptor signaling is modulated by vitronectin receptors in human astrocytoma cells

, : P2y2 nucleotide receptor signaling is modulated by vitronectin receptors in human astrocytoma cells. Society for Neuroscience Abstract Viewer & Itinerary Planner : Abstract No 515 1

Nucleotides released into the extracellular space from injured or dying neural cells can activate astrocytes via P2Y2 nucleotide receptors. It is recognized, that an RGD sequence in the first extracellular loop of the heptahelical P2Y2 nucleotide receptor interacts with vitronectin receptors and is required for effective signal transduction to focal adhesion kinase (FAK) and extracellular signal regulated kinases (ERK) 1/2. Our results demonstrate the importance of this interaction for P2Y2 mediated regulation of cell proliferation via the intracellular mitogen activated protein kinases (MAPK) cascade. Ligation of vitronectin receptors with specific antibodies caused an inhibition of P2Y2 receptor-induced extracellular signal regulated kinases (ERK1/2) and p38 phosphorylation. Coupling of P2Y2 receptor to ERK 1/2 was shown to induce cytoskeletal rearrangements causing membrane ruffles, which are an initial stage of cell motility. Stress fiber rearrangement was independent of P2Y2 receptor dependent p38 activation. Ligation of vitronectin receptors with specific antibodies partially inhibited P2Y2 receptor-induced membrane ruffling and DNA synthesis. These results suggest an important role for the interaction between P2Y2 nucleotide and vitronectin receptors in neural cells plasticity.


Other references

Laroche, F.; Perrot, S.; Menkés, C.J., 1996: Pancytopenia in rheumatoid arthritis patients receiving methotrexate. Revue du Rhumatisme 63(5): 381-382

Hanny, B.W.; Henson, R.D.; Thompson, A.C.; Gueldner, R.C.; Hedin, P.A., 1972: Identification of carotenoid constituents in hibiscus syriacus. The 10 carotenoid pigments found in the bud, leaf and flower of H. syriacus were each identified and quantified. Those most abundant in the buds and leaves were beta -carotene and lutein; lutein 5,6-epoxide predominated in the flower. Carotene hyd...

Donner, F., 1951: Exceptional treaties on nasal ailments. Journal of the American Institute of Homeopathy 44(3): 63-65

Kaye, P.M.; Coburn, C.; McCrossan, M.; Beverley, S.M., 1993: Antigens targeted to the Leishmania phagolysosome are processed for CD4+ T cell recognition. Genetic transformation was used to determine whether the phagolysosome (PL) formed in activated macrophages after ingestion of Leishmania parasites is also a site for entry of antigen into the Class II presentation pathway. Leishmania were transfe...

Mora-Escudero, I.; Gato-Díez, A.; Blázquez-Cabrera, J.A.; Lozano-Setien, E.; García-de-la-Torre, J.P., 2012: Pretibial brown tumors as first manifestation of primary hyperparathyroidism. Revista Clinica Espanola 212(3): E15-E18

Numata, M.; Nagashima, Y.; Moore, M.L.; Berry, K.Z.; Chan, M.; Kandasamy, P.; Peebles, R.Stokes.; Murphy, R.C.; Voelker, D.R., 2014: Phosphatidylglycerol provides short-term prophylaxis against respiratory syncytial virus infection. Respiratory syncytial virus (RSV) causes respiratory tract infections in young children, and significant morbidity and mortality in the elderly, immunosuppressed, and immunocompromised patients and in patients with chronic lung diseases. Recently,...

Goto, F.; Tsutsumi, T.; Oishi, N.; Mimura, M., 2012: Hidden depression in otolaryngology patients with medically unexplained symptoms. To investigate the prevalence of depression among otolaryngology patients with medically unexplained symptoms (MUS) and the outcome of treatment with selective serotonin reuptake inhibitors (SSRIs). Ninety patients with MUS from a population of 98...

Young, G.; Goujet, D., 2003: Devonian fish remains from the Dulcie Sandstone and Cravens Peak Beds, Georgina Basin, central Australia. Fossil fish remains belonging to the Wuttagoonaspis assemblage are described from the Devonian rocks of the Georgina Basin, central Australia. The study is based on some 450 samples from 30 localities in the lower Dulcie Sandstone of the Dulcie Sy...

Poliakova, G.G.; Poliak, L.M.; Litvina, V.I., 1981: Health and hygiene service for the miners of the Kuzbass coal mines. Gigiena Truda i Professional'nye Zabolevaniia: 43-44

Simon, K., 1977: Immunoprophlaxis of tuberculosis. Das Offentliche Gesundheitswesen 39(3): 133-136