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P53 as a regulator of cell differentiation


, : P53 as a regulator of cell differentiation. Official Gazette of the United States Patent & Trademark Office Patents 1264(2), Nov 12

The present invention involves the role of p53 in the differentiation of embryonic tissues. More particularly, the present invention provides methods of the blocking of p53 function in embryonic tissues, and the use of these tissues as screening tools for substances that are capable of overcoming the p53-related block in differentation, both in vitro and in vivo. The similarities between undifferentiated embryonic cells and tumor cells is evident, and thus these assays serve as a model for possible cancer therapeutics. In addition, methods for identifying additional cellular components that interact p53 or p53-related pathways are provided.

US$29.90


Other references

Rosin, L.; Berger, F., 1999: Transcatheter closure of patent foramen ovale in patients with paradoxical embolism. Neurology 52(6 SUPPL 2): A63-A64, April 12

Dunn, P.A.; Bhutani, V.; Weiner, S.; Ludomirski, A., 1988: Care of the neonate with erythroblastosis fetalis. Erythroblastosis fetalis, hemolytic disease of the newborn, occurs when an isoimmunized mother produces antibodies that cross the placenta and cause hemolysis of fetal red blood cells. This hemolysis can be accompanied by severe anemia, ascites, p...

Frye, C.A.; Sumida, K.; Lydon, J.P.; O'Malley, B.W.; Pfaff, D.W., 2006: Mid-aged and aged wild-type and progestin receptor knockout (PRKO) mice demonstrate rapid progesterone and 3alpha,5alpha-THP-facilitated lordosis. Progesterone (P) and its 5alpha-reduced metabolite, 3alpha-hydroxy-5alpha-pregnan-20-one (3alpha,5alpha-THP), facilitate sexual behavior of rodents via agonist-like actions at intracellular progestin receptors (PRs) and membrane GABA(A)/benzodiaze...

Tang, L.Q.; Guo, X.A.; Zhang, M.S., 1997: Epidemiological trend and its impact on malaria control programme in Shenzhen from 1950-1995. Shenzhen has been developed as the first economic special zone in China. Two large scale outbreaks of vivax malaria have occurred in the history. Anopheles anthropophagus has been identified as the major vector. For the last 45 years, we have adop...

Hoebink, E.A.; Journée, H.L.; de Kleuver, M.; Berends, H.; Racz, I.; van Hal, C., 2016: Movement Along the Spine Induced by Transcranial Electrical Stimulation Related Electrode Positioning. A prospective, nonrandomized cohort study. To describe a technique quantifying movement induced by transcranial electrical stimulation (TES) induced movement in relation to the positioning of electrodes during spinal deformity surgery. TES induced...

Bui, Déborah.S.S.; Seguro, Aônio.C.; Shimitzu, M.H.; Schliemann, I.; Martini, D.; Romão, Jão.E.; Pecoits Filho, R.F.; Abensur, H., 2012: N-Acetylcysteine protects the peritoneum from the injury induced by hypertonic dialysis solution. Oxidative stress has been implicated in the development of peritoneal damage. The aim of this study was to evaluate the effects of N-acetylcysteine (NAC) in a rat peritoneal infusion model. Eighteen male Wistar rats were divided in 3 groups: (i) c...

Valerius, T.; Tiemann, B., 1974: Anesthesia and intensive care. IV. Diagnostic and therapeutic nerve blocks. Krankenpflege 28(4): 148-149

Mach, J., 2012: TERMINAL FLOWER1 acts in transcriptional repression. Plant Cell 23(9): 3084-3084

Coetzer, B.R., 2004: Management of post-concussion syndrome. British Journal of Psychiatry 184: 86-87

Cedars, M.I., 2015: Diminished ovarian reserve. How do you diagnosis it? What does it mean?. Seminars in Reproductive Medicine 31(6): 391-392