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P53 hemizygous knockout mice but not APC knockout mice enhance gastric mucosal inflammation induced by H pylori

, : P53 hemizygous knockout mice but not APC knockout mice enhance gastric mucosal inflammation induced by H pylori. Gastroenterology. 122(4 Suppl. 1): A-173, Il

H.pyloriplays a critical role in the pathogenesis of peptic ulcers and the chronic inflammatory process which may be linked to gastric cancer, p53 inhibits cell growth through the activation of cell-cycle arrest and apoptosis and most cancers have eitherp53 gene mutation or defects in p53 induction. Mutations in APCgene appear to be responsible not only familial adenomatous polyposis but also sporadic gastric cancer. To determine the role of p53 and APC mutation in the development of gastric carcinogenesis, p53 hemizygous and APC knockout mice were infected with H.pylori. Method: H.pylori strain TN2GF4 which has been reported to induce gastric cancer in Mongolian gerbils was inoculated into both wild type B57 mice an d p53 hemizygous mice. Mice were sacrificed at 6 and 12 months after inoculation. H.pyloriinfection and grade of histological gastritis were assessed. The antibody titer against H.pylori were also examined. APC knockout mice were also studied for up to 6 months. Results: infected animals developed anti-H.pylori serum IgG responses. One year after infection with H.pylori, p53 hemizygous mice showed more active chronic inflammation than wild type mice~ The inflammation score assessed by the updated Sydney System in p53 hemizygous and wild mice were 2.1,1.4, respectively (p


Other references

Klissiunis N.; Triantaphyllou I., 1973: Contributions to the action of l dopa. Naunyn-Schmiedeberg's Archives of Pharmacology 279(SUPPL): R-36

Leonard, C.D., 1970: A comparison of soil and spray applications of four manganese sources for control of manganese deficiency in 'Valencia' orange trees. In a 5-year study soil treatment with either powdered or granular manganese sulfate applied alone or mixed in fertilizer gave much higher leaf Mn and better control of Mn chlorosis than manganous oxide or tribasic manganese sulfate applied similar...

Otto, D.M.E.; Moon, T.W., 1996: Phase I and II enzymes and antioxidant responses in different tissues of brown bullheads from relatively polluted and non-polluted systems. Brown bullheads (Ameiurus nebulosus) were collected from the St. Lawrence River and compared in their detoxication capacities to bullheads from a relatively non-polluted aquatic system, Lac La Pêche. The content of polychlorinated biphenyls (PCBs...

Bull, R.; Chamorro, A.; Catalan, M.; Finkelstein, J.P.blo, 2002: Magnesium inhibition of single cardiac RyR channels. Biophysical Journal 82(1 Part 2): 73a, January

Franklin, C.W., 1972: Punishment and frustration: serendipitous findings. Thirteen patients with Wilson's disease were compared with seven cirrhotic and 13 normal controls to define better the haematological abnormalities in this condition. Hypersplenism (anaemia, leukopenia, thrombocytopenia, and reduced red cell...

Domingo, E.; Gordon, C.N.; Warner, R.C., 1972: Azotobacter phages: properties of phages A12, A21, A31, A41 and their constituent DNAs. Virology 49(2): 439-452

Sindermann F.; Deecke L., 1970: Subjective intensity of the hermann grid phenomenon in the peripheral retina as related to receptive field organization. Pfluegers Archiv European Journal of Physiology 316(3-4): R95

Ruoslahti, E.; Ehnholm, C.; Makela, O., 1967: A weak B blood group in a Finnish family. The 4 members of this family with the rare blood group have the weak B antigen on the red cells, anti-B in the serum, and one member secretes a small amount of B antigen into his saliva. The frequency of this Bv which is only 0.134 is higher in Fi...

Waterfield, M.D.; Prahl, J.W.; Hood, L.E.; Kindt, T.J.; Krause, R.M., 1972: Restricted structural heterogeneity in antibodies: might different heavy chains have a common light chain?. Nature: New Biology 240(102): 215-217

Laws, J., 2008: Toward a healthier bottom line. Occupational Health & Safety 77(9): 80, 82, 84-80, 82, 84