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Plasma hepatocyte growth factor is prognostic factor in patients with acute myeloid leukemia but not in patients with myelodysplastic syndrome


, : Plasma hepatocyte growth factor is prognostic factor in patients with acute myeloid leukemia but not in patients with myelodysplastic syndrome. Blood 96(11 Part 1): 104a, November 16

Hepatocyte growth factor (HGF) is a potent angiogenic factor that has many other biological activities. It induces proliferation, migration, and invasion of endothelial cells, morphogenesis of new vessels, and production of other angiogenic factors. HGF has been associated with cancer progression and poor outcome in patients with solid tumors and multiple myeloma. Its significance in leukemia has not been fully evaluated. The aims of our study were to evaluate plasma HGF levels and their prognostic significance in patients with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). The sandwich enzyme immunoassay technique was used to quantify HGF levels in stored samples obtained before treatment from patients with AML (59 patients) and MDS (42 patients) treated at The University of Texas M. D. Anderson Cancer Center. HGF levels were significantly higher in patients with AML (median 854.8 pg/ml) or MDS (median 843.5 pg/ml) than in healthy individuals (median 364.2 pg/ml) (P < 0.0001). Higher HGF levels in both AML and MDS correlated significantly with while blood cell (P = 0.000001 for both groups) and monocyte counts (P = 0.0004 and 0.003, respectively), and with poor performance status (P = 0.03 and 0.001, respectively). Using Cox proportional hazard model and HGF levels as a continuous variable, plasma levels of HGF correlated with shorter survival of AML (P < 0.002) but not MDS (P = 0.34) patients. No significant correlation was observed between HGF levels and complete remission rate or duration in AML or MDS patients.

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