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Preclinical evaluation of PEG-L-asparaginase treatment for pancreatic cancer


, : Preclinical evaluation of PEG-L-asparaginase treatment for pancreatic cancer. Proceedings of the American Association for Cancer Research Annual Meeting 40: 343-344, March


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Hayashi, T.; Desmeules, P.; Smith, R.S.; Drilon, A.; Somwar, R.; Ladanyi, M., 2017: RASA1 and NF1 are preferentially co-mutated and define a distinct genetic subset of smoking-associated non-small cell lung carcinomas sensitive to MEK inhibition. Ras-GTPase activating proteins (RasGAPs), notably NF1 and RASA1, mediate negative control of the RAS/MAPK pathway. We evaluated clinical and molecular characteristics of NSCLC with RASA1 mutations in comparison with NF1-mutated cases. Large genomi...

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Namaste, S.Ml.; Rohner, F.; Huang, J.; Bhushan, N.L.; Flores-Ayala, R.; Kupka, R.; Mei, Z.; Rawat, R.; Williams, A.M.; Raiten, D.J.; Northrop-Clewes, C.A.; Suchdev, P.S., 2017: Adjusting ferritin concentrations for inflammation: Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project. <b>Background:</b> The accurate estimation of iron deficiency is important in planning and implementing interventions. Ferritin is recommended as the primary measure of iron status, but interpretability is challenging in settings with...

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