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Radioimmunoimaging and radioimmunotherapy: will these be routine procedures?


, : Radioimmunoimaging and radioimmunotherapy: will these be routine procedures?. Seminars in Nuclear Medicine 30(3): 186-194

Despite major progress made during the past 25 years in the genetic engineering and labeling of monoclonal antibodies (Mab) and in the understanding of the uptake and kinetics of radiolabeled Mab by normal and tumor tissues, immunoscintigraphy never succeeded in becoming a routine procedure, compared with a bone or gallium scan. The more and more generalized availability of positron emission tomography (PET) with Fluorine-18 fluorodeoxyglucose (FDG) for diagnosis and staging of malignant diseases will probably definitively seal the fate of radioimmunodiagnosis as it has been conceived up until now. With respect to the nonspecificity of deoxyglucose uptake by tumor cells, it is not to be excluded that antibodies, or more likely antibody fragments, labeled with positron emitters might be used for tissue characterization. The recent success of radioimmunotherapy, especially in B-cell malignancies, entitles us to expect that RIT will become part of standard therapy of patients with malignancies. In that case, immunoscintigraphy will be needed for treatment planning (patient selection and dosimetry). One might even speculate that the oncologists who are becoming familiar with nuclear medicine tracer techniques for pretreatment evaluation might be interested in extending them to distribution and kinetic studies of other cytotoxic drugs. The close cooperation between nuclear medicine specialists, oncologists, and hematologists is essential to make radioimmunotherapy a routine procedure.

US$19.90

PMID: 10928382

DOI: 10.1053/snuc.2000.7440


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Roll, P.; Zattara Cannoni, H.; Bustos Bernard, M.C.ristine; Curtillet, C.; Michel, G.; Vagner Capodano, A.M.rie, 2002: Molecular and fluorescence in situ hybridization analysis of a 10;11 rearrangement in a case of infant acute monocytic leukemia. Fluorescence in situ hybridization (FISH) analysis in a case of infant acute monocytic leukemia M5 revealed a complex rearrangement between chromosomes 10 and 11, leading to the disruption of the MLL gene. Using two painting probes for chromosomes...

Badimon, L., 2001: Atherosclerosis and thrombosis: lessons from animal models. Atherothrombosis defines the occurrence of thrombosis on atherosclerotic lesions. Atherosclerosis is the most prevalent disease of our time and its thrombotic complications are responsible for an exceedingly high number of deaths and disabilities....

Oser, B.L.; Melnick, D.; Pader, M., 1943: Chemical and physical determinations of vitamin A in fish liver oils. The ultraviolet spectrophotometric absorption curves of various fish liver oils and of pure vitamin A and vitamin A acetate were plotted by taking the ratio of extinctions, at different wave lengths, rather than the extinction coefficients themsel...

Swezey, O.H., 1938: Records of immigrant insects for the year 1937. Proceedings of the Hawaiian Entomological Society, 10: 174

Gollan, J.S., 1946: La Comadrejita Enana, Dromiciops australis australis (F. Philippi). Holmbergia Buenos Aires, 49: 101-195

Markovich, N.Ia.; Zarechnaia, S.N., 1992: Data on the spread of Culex pipiens on the territory of the USSR. A map of Culex pipiens molestus distribution over the USSR was made using data of sanitary epidemiological stations of various regions of the country, literature and the authors' own data. It was shown that during the last decades (1978-1990)...

Wierda, W.G., 2006: Current and investigational therapies for patients with CLL. Clinical and laboratory investigations are driving the rapid change in treatments for patients with chronic lymphocytic leukemia (CLL). Randomized trials have demonstrated superior activity for fludarabine combined with cyclophosphamide versus sin...

Doyle, J.P.; Parker, R.M.; Jacobson, T.A.; McNagny, S.E., 1996: Breast and cervical cancer screening in an inner-city medical walk-in clinic: taking advantage of an often missed opportunity. Background: Despite established evidence that screening for breast and cervical cancer reduces mortality in women, screening is underutilized, especially in poor, minority women. We hypothesized that a high percentage of women presenting for care...

Nasz, I.; Toth, M., 1959: Cytomorphological changes in human embryonic kidney tissue cultures infected with adenovirus type 5 strains. Acta Microbiologica Academiae Scientiarum Hungaricae 6: 85-92

Drougia, A.; Giapros, V.; Hotoura, E.; Papadopoulou, F.; Argyropoulou, M.; Andronikou, S., 2008: The effects of gestational age and growth restriction on compensatory kidney growth. Low birth weight is associated with altered renal development, adult onset hypertension and renal disease. The aim of this prospective longitudinal study was to estimate the renal growth during the first 2 years of life in small-for-gestational ag...