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Sex differentiated hypothalamic activation by putative pheromones

, : Sex differentiated hypothalamic activation by putative pheromones. Molecular Psychiatry 7(4): 335-336

The cellular prion protein (PrPc) is a sialoglycoprotein involved in the pathogenesis of prion diseases. It has been identified at the plasma membrane of several cell types. All-trans retinoic acid (ATRA) is known to induce differentiation of human leukemia cell lines in vitro. PrPc messenger ribonucleic acid (mRNA) and protein are down-regulated upon ATRA-induced differentiation of HL60 cells. In this report, we have investigated the regulation of PrPc mRNA and protein expression during ATRA-treatment of maturation-sensitive (NB4) and -resistant (NB4-R1 and NB4-R2) cell lines. In ATRA-induced maturation of NB4 cells, down-regulation of PrPc mRNA and protein were observed. We also show that down-regulation of PrPc mRNA is dependent on protein synthesis. Moreover, the same down-regulation of prion protein by ATRA was observed at the surface of maturation-resistant, ATRA-responsive NB4-R1 cells. In contrast, the maturation-resistant and ATRA-unresponsive NB4-R2 subline showed no variation in membrane prion protein expression. These results demonstrate a dissociation between the regulation of prion protein expression by ATRA and the process of granulocyte maturation. We propose that retinoids should be investigated further as a preventive strategy to slow down prion disease progression.


PMID: 11986975

DOI: 10.1038/

Other references

Anonymous, 1967: Abstracta. Sixth International Congress of Plant Protection, Vienna, 30 Aug.-6 Sept. 1967. In sect. BI of the abstracts (in Germ., Engl., and Fr.) from this congress, sponsored by the Pesticides Sect., Int. Union of Pure and Applied Chemistry, the topics discussed were biological and cultural control methods and included papers on disea...

Puente, A.E., 2012: Antonio E. Puente: Award for Distinguished Professional Contributions to Independent Practice. Presents Antonio E. Puente as the 2011 winner of the American Psychological Association Award for Distinguished Professional Contributions to Independent Practice. "For his decades of efforts to enhance the recognition of psychologists in pro...

Pellizzaro, G.; Ventura, A.; Arca, B.; Canu, A., 1998: A non-destructive method to determine leaf chlorophyll content in grain sorghum. In a trial in Ottava, Italy, the SPAD-502 leaf chlorophyll meter was used to measure total chlorophyll content of sorghum cv. NK 121, NK 180 and Aralba given different irrigation and N fertilizer treatments. During the growing season measurements...

Bonofiglio, A.; Bugaro, L.; Pantaleoni, A., 1967: On a case of atrial fibrillation during cranial trauma. Bollettino Della Societa Italiana di Cardiologia 12(6): 859-865

Bowen, J.T.; Wolbach, S.B., 1906: A Case of Blastomycosis: The results of Culture and Inoculation Experiments. Journal of Medical Research 15(1): 167-178.3

Balogh Kalman; Kovacs Sandor, 1976: Sphinctozoa from the reef facies of the Wetterstein Limestone of Alsohegy-mount (South Gemericum, West Carpathians, northern Hungary). Acta Mineralogica-Petrographica (Szeged) 22(2): 297-310

Zubkov, A.Y.; Aoki, K.; Parent, A.D.; Zhang, J.H., 2002: Preliminary study of the effects of caspase inhibitors on vasospasm in dog penetrating arteries. This preliminary study was undertaken to explore the possible protective effect of caspase inhibitors Z-VDVAD-FMK and Z-DEVD-FMK in apoptosis and vasospasm in penetrating arteries during cerebral vasospasm. Experimental subarachnoid hemorrhage (SA...

Samborski, Z., 1965: Studies on the catalase activity of cows' milk. A simplified Klisiecki method was studied with milk samples from 35 cows (with healthy udders) of different age, stage of lactation and pregnancy and daily yields. The correlation coefficient between this test and that of Warburg was 0.9978 (P=0.0...

Govindan, R.; Sannappa, B.; Bharathi, V.P.; Singh, M.P.; Hegde, D.M., 2002: Elemental composition of leaves of different varieties of castor, Ricinus communis L. A study was conducted in Karnataka, India to analyse the elemental composition of castor cultivars (Local Pink, powdery; Local Pink, non-powdery; Local Green, powdery; Local Green, non-powdery; DCH-32, DCH-177, DCS-9 and 48-1) to select best culti...

Shukry, H.; Awwad, S.; Attia, O., 1954: Wilm's tumour, with a report of one case. Journal of the Egyptian Medical Association 37(6): 655-659