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Solid-phase synthesis of codeine from morphine

, : Solid-phase synthesis of codeine from morphine. Official Gazette of the United States Patent & Trademark Office Patents 1228(2), Nov 9

The specification describes a methylation resin comprising methyl(dialkyl)anilinium salts or methyl(diaryl)anilinium salts covalently bonded to the resin. The methylation resin is used in the solid-phase synthesis of codeine from morphine. Accordingly, the specification describes a process for methylating morphine to form codeine by loading morphine onto a methylation resin comprising methyl(dialkyl)anilinium salts or methyl(diaryl)anilinium salts covalently bonded to the resin; contacting the loaded resin with sufficient hydrocarbon or ether solvent to cover the loaded resin; and heating the loaded resin in the hydrocarbon or ether solvent under sufficient conditions to form codeine. The methylating resin may be used to methylate phenolic moieties on other compounds and to esterify compounds containing carboxylic acid moieties.


Other references

Kotel'nikova, R.A.; Tat'ianenko, L.V.; Mekler, V.M.; Kotel'nikov, A.I., 1982: Study of catalytically active center of the Ca2+-Mg2+-dependent ATPase of sarcoplasmic reticulum by triplet probe method. It was shown that eosine and erythrosine are competing inhibitors of the Ca2+-Mg2+- dependent ATPase active center of sarcoplasmic reticulum. The eosine and erythrosine inhibition constants are equal to 1.4 x 10(-6) M and 1.1 x 10(-6) M, respectiv...

Kubota Y., 1987: In vitro and in vivo differentiation of leukemic cells induced by vitamin d 3. Experimental Hematology (charlottesville): 434

Forssmann, W.G.; Brandt, P.W.; Reuben, J.P.; Grundfest, H., 1974: Reversible morphological changes in the contractile sphere of crayfish muscle fibers. Journal of Mechanochemistry & Cell Motility 2(4): 287-293

Blanke, M.M.; Pring, R.J.; Baker, E.A., 1999: Structure and elemental composition of grape berry stomata. Low temperature scanning electron microscopy (LT-SEM) of the surface of fruits of grapes cv. Muller-Thurgau, Riesling, Reichensteiner and Ehrenfelser showed that peristomatal protuberances of up to 200 micro m diameter developed 2 weeks after anth...

Lucas M.; Galvan A.; Solano F., 1985: Stimulation by calcium and carbamoylcholine of the ouabain sensitive uptake of rubidium 86 in isolated rat pancreatic acinar cells. The uptake of 86Rb+ was assayed in isolated rat pancreatic acinar cells to determine the effect of Ca and carbamoylcholine on the ouabain-sensitive and ouabain-insensitive components. The presence of Ca in the medium bathing the cells during the p...

Grabener, E., 1963: On The Diagnosis Of Uremia. Munchener Medizinische Wochenschrift 105: 1604-1608

Hussain, M.D.lwar; Micetich, R.; Shysh, A.; Suresh, M., 1996: Studies on the hemagglutinin from canola seeds. Pharmaceutical Research (New York) 13(9 SUPPL ): S146

Shepovalnikov A.N.; Tsitseroshin M.N.; Apanasionok V.S.; Rozhkov V.P., 1981: On normative characteristics of brain bio potential fields in children and adults. Electroencephalography & Clinical Neurophysiology 52(3): S12

Paredes, R.; Puig, T.; Arnó, A.; Negredo, E.; Balagué, M.; Bonjoch, A.; Jou, A.; Tuldrà, A.; Tural, C.; Sirera, G.; Veny, A.; Romeu, J.; Ruiz, L.; Clotet, B., 2000: High-dose saquinavir plus ritonavir: long-term efficacy in HIV-positive protease inhibitor-experienced patients and predictors of virologic response. The year-long antiviral efficacy of a high-dose salvage regimen consisting of saquinavir (800 mg twice daily) plus ritonavir (400 mg twice daily) was evaluated in 58 HIV-positive patients who had seen no improvement under first-line protease inhib...

Chapa, A.M.; Fernandez, J.M.; Mccormick, M.E.; Beatty, J.F., 1998: Supplemental dietary protein effects on the energy status of grazing dairy cows Year II. Journal of Dairy Science 81(4): 1187, April