+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Spectroscopic characterization of chemokines: relevance for quality control and standardization

, : Spectroscopic characterization of chemokines: relevance for quality control and standardization. Developments in Biological Standardization 97: 49-57

Chemokines are mediators of inflammation and trafficking of cells of the immune system including a pivotal role in the recruitment and activation of leukocytes. Due to their involvement in a variety of disease processes, chemokines are potential therapeutic targets. The use of chemokines as pharmaceuticals will require that the folded state and the association properties of the protein are well characterized. In this report, we describe the utility of nuclear magnetic resonance spectroscopy as a tool to study these aspects of chemokine structural properties.


PMID: 10463530

Other references

Roduit, R.; Masiello, P.; Wang, S.P.; Li, H.; Mitchell, G.A.; Prentki, M., 2001: A role for hormone-sensitive lipase in glucose-stimulated insulin secretion: a study in hormone-sensitive lipase-deficient mice. Endogenous lipid stores are thought to be involved in the mechanism whereby the beta-cell adapts its secretory capacity in obesity and diabetes. In addition, hormone-sensitive lipase (HSL) is expressed in beta-cells and may provide fatty acids nec...

Grishina T.I.; Aizina N.L.; Babok A.L.; Alekseeva O.G., 1989: Histamine dependent reactions in patients with byssinosis. Gigiena Truda i Professional'nye Zabolevaniya (4): 22-24

Nilovskaya N.T., 1969: Gas exchange of some vegetables with increased oxygen content in a gaseous environment potato d cabbage d beet d. Kosmicheskaya Biologiya I Meditsina: 20-25

Rondepierre, J.J.; Ropert, R.; Azoulay, J., 1962: On the clinical use in neuro-psychiatry of the ethyl-3- 10 phenothiazine hydrochloride , a new pheno-thiazinic neuroleptlc drug. Presse Med 70(27): 1342-1344

Zhang, L.; Hu, M.; Chilton, N.B.; Huby-Chilton, F.; Beveridge, I.; Gasser, R.B., 2006: Nucleotide alterations in the D3 domain of the large subunit of ribosomal DNA among 21 species of equine strongyle. The expansion segments or divergent (D) domains in the large subunit (LSU) of the ribosomal DNA have been suggested as genetic markers for taxonomic and/or phylogenetic studies of parasites. In the present study, we assessed the degree of sequenc...

Ham, C.; Williams, I.; D.S.lva, D., 2010: Innovation. Switch on your culture of ideas. Health Service Journal 119(6182): 20-21

Nellen, R.G.L.; Van Geel, M.; Huijbregts, K.M.L., 2016: Response to 'Darier disease in Israel: combined evaluation of genetic and neuropsychiatric aspects'. British Journal of Dermatology 175(1): 223-224

Diaconitza G.; Nicolesco P.; Ionesco V.; Mandache E., 1972: The ultrastructural study of bronchial carcinoid. Morgagni 5(1): 27-30

Roch, A.M.; Ceppa, E.P.; Al-Haddad, M.A.; DeWitt, J.M.; House, M.G.; Zyromski, N.J.; Nakeeb, A.; Schmidt, C.Max., 2014: The natural history of main duct-involved, mixed-type intraductal papillary mucinous neoplasm: parameters predictive of progression. As such, the natural history of MPD-involved IPMN is poorly understood. The high-risk of malignancy associated with main pancreatic duct (MPD)-involved intraductal papillary mucinous neoplasm (IPMN) has been established by surgical series. The Int...

Korotaeva, T.V.; Novikoya, D.S.; Loginova, E.Yu., 2016: Cardiovascular risk in patients with psoriatic arthritis. Psoriatic arthritis (PsA) is a chronic.immune-mediated disease that is observed in 8-30% of psoriatic patients. It has been recently established that PsA and psoriasis are closely associated with the high prevalence of metabolic syndrome, hyperten...