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Structural studies of prokaryotic RNA polymerases


, : Structural studies of prokaryotic RNA polymerases. FASEB Journal 15(5): A1082, March 8

The 3.3 ANG-resolution X-ray crystal structure of Thermus aquaticus core RNA polymerase provides a basis for further structural and functional studies. The path of the transcript RNA and template DNA through the RNA polymerase structure was tracked using RNA-protein and DNA-protein crosslinks, resulting in a model of the ternary elongation complex. A co-crystal structure of core RNA polymerase complexed with rifampicin reveals the structural basis of the antibiotics' inhibition mechanism.

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