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The effect of gender, estrus status and plasma homocysteine on intimal hyperplasia after a rat carotid endarterectomy


, : The effect of gender, estrus status and plasma homocysteine on intimal hyperplasia after a rat carotid endarterectomy. FASEB Journal 17(4-5): Abstract No 216 24, March

)Objective: Intimal hyperplasia (IH) can diminish the effectiveness of many vascular procedures. This study was designed to investigate how gender and estrogen status affects the IH response and plasma homocysteine in a rat carotid endarterectomy (CEA) model.)Method:)5 groups of rats underwent CEA with vein patch closure; male (ML, n=11); female in estrus (FIE, n=10); female out of estrus (FOE, n=12); ovariectomized (OVX, n=10) and OVX with 0.5 mg 17-beta estradiol pellet added (OVX-E, n=11). Groups were subdivided based on diet, control or 4.5 g/kg DL-homocystine. Estrus status was determined by vaginal smears at time of CEA. Two weeks post-CEA, IH and plasma homocysteines were measured.)Results: )There was no difference in IH between male (43 +-11%) and female (57 +-6%) (in and out of estrus combined). Rats in low estrogen status, FOE (47 +-5%), OVX (30 +-7%) and ML (43 +-11%) had a lower degree of IH compared with female rats in a high estrogen state, FIE (73 +-7%), p=0.01, 0.004 and 0.056 respectively. The estrogen in the OVX-E group increased IH response (83.9 +-13%) to levels seen in the FIE group. Homocystine groups had significantly elevated plasma homocysteine and IH.)Conclusion: )High estrogen appears to contribute to a more pronounced IH response. Addition of estrogen to OVX rats result in increased IH and may represent a risk factor for IH.

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