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The effect of gender, estrus status and plasma homocysteine on intimal hyperplasia after a rat carotid endarterectomy

, : The effect of gender, estrus status and plasma homocysteine on intimal hyperplasia after a rat carotid endarterectomy. FASEB Journal 17(4-5): Abstract No 216 24, March

)Objective: Intimal hyperplasia (IH) can diminish the effectiveness of many vascular procedures. This study was designed to investigate how gender and estrogen status affects the IH response and plasma homocysteine in a rat carotid endarterectomy (CEA) model.)Method:)5 groups of rats underwent CEA with vein patch closure; male (ML, n=11); female in estrus (FIE, n=10); female out of estrus (FOE, n=12); ovariectomized (OVX, n=10) and OVX with 0.5 mg 17-beta estradiol pellet added (OVX-E, n=11). Groups were subdivided based on diet, control or 4.5 g/kg DL-homocystine. Estrus status was determined by vaginal smears at time of CEA. Two weeks post-CEA, IH and plasma homocysteines were measured.)Results: )There was no difference in IH between male (43 +-11%) and female (57 +-6%) (in and out of estrus combined). Rats in low estrogen status, FOE (47 +-5%), OVX (30 +-7%) and ML (43 +-11%) had a lower degree of IH compared with female rats in a high estrogen state, FIE (73 +-7%), p=0.01, 0.004 and 0.056 respectively. The estrogen in the OVX-E group increased IH response (83.9 +-13%) to levels seen in the FIE group. Homocystine groups had significantly elevated plasma homocysteine and IH.)Conclusion: )High estrogen appears to contribute to a more pronounced IH response. Addition of estrogen to OVX rats result in increased IH and may represent a risk factor for IH.


Other references

Doutremepuich J.D.; Barbier A.; Lacheretz F., 1992: Action of procyanidolic oligomers pco on edema based on an experimental model acute lymphedema of rats limb. Cluzan, R V , A P Pecking And F M Lokiec International Congress Series, No 994 Progress in Lymphology; Xiiith International Congress Of Lymphology, Paris, France, September 29-October 5, 1991 Xxii+716p Elsevier Science Publishers B V : Amsterdam, Netherlands; Excerpta Medica: London, England, Uk Illus 645-646

Bearce Denny N., 1971: Geology of the Talladega slate belt in Cleburne and Calhoun counties, eastern Alabama. Abstracts with Programs Geological Society of America: Pages 294. 1971.

Goetz, A.; Kerwath, S.E.; Attwood, C.G.; Sauer, W.H.H., 2007: Comparison of the effects of different linefishing methods on catch composition and capture mortality of South African temperate reef fish. The effects of hook size, bait type, water depth and fishing effort on the selectivity and capture mortality of reef fish were investigated in a standardised fishing experiment on the temperate south coast of South Africa. A total of 2 406 fish wa...

Kuo, T-Chun.; Li, L-Wei.; Pan, S-Hua.; Fang, J-Min.; Liu, J-Hurng.; Cheng, T-Jen.; Wang, C-Jen.; Hung, P-Fang.; Chen, H-Yu.; Hong, T-Ming.; Hsu, Y-Ling.; Wong, C-Huey.; Yang, P-Chyr., 2016: Purine-Type Compounds Induce Microtubule Fragmentation and Lung Cancer Cell Death through Interaction with Katanin. Microtubule targeting agents (MTAs) constitute a class of drugs for cancer treatment. Despite many MTAs have been proven to significantly improve the treatment outcomes of various malignancies, resistance has usually occurred. By selection from a...

Simón, M.A.; Yangüela, J.M.; Ricarte, E.; Ochoa, J., 1987: Toxic megacolon caused by Salmonella enteritidis. Revista Espanola de Las Enfermedades del Aparato Digestivo 72(1): 88-89

Kuhtz, E.H., 1952: Homeoplastic transplantations of the esophagus. Zentralblatt für Chirurgie 77(43a): 2076-2079

Maller, J.L., 2012: Pioneering the Xenopus oocyte and egg extract system. Journal of Biological Chemistry 287(26): 21640-21653

Asztemborska, M.; Bielejewska, A.; Duszczyk, K.; Sybilska, D., 2000: Comparative study on camphor enantiomers behavior under the conditions of gas-liquid chromatography and reversed-phase high-performance liquid chromatography systems modified with alpha- and beta-cyclodextrins. The dependence of retention and selectivity parameters of camphor enantiomers on the concentration of alpha- and beta-cyclodextrins were studied under conditions of GLC (matrix solvent: Glycerol, 95 degrees C) and RP-HPLC (matrix solvent: Aqueous...

Turner, S.M.; Probert, C.S.J., 2003: Evidence for the clinical use of infliximab in Crohn's disease. Romanian Journal of Gastroenterology 12(1): 2-5

Chandler G.T.; Fleeger J.W., 1984: Tube building by a marine meiobenthic harpacticoid copepod. Pseudostenhelia wellsi Coull and Fleeger is a meiobenthic harpacticoid copepod inhabiting muddy, estuarine sediments. All individuals observed, and all ages including nauplii, build and inhabit elongate, mucous tubes which may extend to a depth of...