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The establishment and maintenance of DNA methylation patterns in mouse somatic cells

, : The establishment and maintenance of DNA methylation patterns in mouse somatic cells. Seminars in Cancer Biology 9(5): 329-337

Somatic cell DNA methylation patterns in mammals are established during embryonic development and are then maintained somewhat faithfully for the remainder of the individual's lifetime. Pattern formation can be divided into a series of linked steps that include demethylation, de novo methylation, methylation spreading, methylation blocking, and maintenance methylation. In this review, these steps will be combined to present a model for the formation and maintenance of a methylation pattern in the 5' region of the mouse Aprt gene. This model suggests that an apparently 'stable' methylation pattern results from a dynamic equilibrium between forces that promote and inhibit methylation spreading.


PMID: 10547341

DOI: 10.1006/scbi.1999.0133

Other references

Stavinoha W.B., 1976: The study of brain metabolism through microwave heating. Psychopharmacology Bulletin 12(2): 59-60

Homoud M.K.; Haft K.I.; Goldstein J.E.; Aaronoff M., 1991: Timing of repeat angioplasty in symptomatic post ptca patients a clue to restenosis or new coronary lesions. Clinical Research 39(2): 399A

Shepelev, A.P., 1977: Lipid peroxidation in the brains of warm-blooded animals during acute physical overheating. Izvestiia Akademii Nauk Sssr. Seriia Biologicheskaia: 628-632

Felmy Andrew R.; Rustad James R.; Dixon D.A., 1999: The surface charging of Fe(III)/ Fe(II) oxyhydroxides in aqueous solutions; use of molecular level simulations to assess site binding. Abstracts of Papers American Chemical Society, National Meeting: Part 1, Pages ; unpaginated. 1999.

Carrillo, M.T.; Garcia Larrea, L., 1999: On the validity of interblock averaging of P300 in clinical settings. The reduction of long-latency auditory ERPs amplitude, including P300, to repeated stimuli has been well documented in the literature on habituation. The effect of block repetition on auditory ERPs recorded for clinical purposes, where interblock...

Amann R.; Donnerer J.; Maggi C.A.; Giuliani S.; Delbianco E.; Weihe E.; Lembeck F., 1990: Capsaicin desensitization in vivo is inhibited by ruthenium red. The effect of systemic administration of Ruthenium Red on the excitatory and desensitizing effect of capsaicin was investigated in rats. Ruthenium Red was injected s.c. 30 min before capsaicin was administered. The excitatory effect of capsaicin o...

Dupont, P., 1984: The herbicide market. Cultivar (178) 203

Kohnen, T., 2004: Combining wavefront and topography data for excimer laser surgery: the future of customized ablation?. Journal of Cataract and Refractive Surgery 30(2): 285-286

Dubiel, B.T.; Czyrska-Filemonowicz, A., 2010: Microstructural changes during creep of CMSX-4 single crystal Ni base superalloy at 750 degrees C. TEM studies of creep tested CMSX-4 nickel-base single crystal superalloy were performed to analyse a microstructure evolution during creep at temperature 750 degrees C, and uniaxial tensile stress of 675 MPa. Microstructural analyses were focused...

Bremer K., 1987: Tribal interrelationships of the asteraceae. A cladistic analysis involving 27 tribes and subtribes of Asteraceae and 81 characters is presented. The terminal taxa are mainly those of present tribal classification, though some apparently poly-and paraphyletic tribes, notably the Mutisiease a...