+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

The role of CamKII during sensitization in the medicinal leech

, : The role of CamKII during sensitization in the medicinal leech. Society for Neuroscience Abstracts 27(1): 234

Calcium-calmodulin dependent protein kinase II (CamKII) has been shown to participate in a number of cellular events that contribute to learning and memory in both invertebrates and vertebrates. Using the medicinal leech, Hirudo medicinalis, we will assess the role of CamKII during sensitization of the leech whole body shortening reflex. Sensitization is a form of non-associative learning where a behavior is enhanced following delivery of a strong, usually noxious, stimulus. The cellular mechanisms that mediate sensitization are of interest because they are thought to contribute to more complex, associative forms of learning. The leech is an ideal system for studying the physiological basis of learning because its nervous system is well characterized and individual neurons have been identified that are critical for sensitization of the shortening reflex. Using both Western blot analysis and whole-mount immunohistochemical staining, we have detected a CamKII-like protein in the leech central nervous. The potential role of CamKII in sensitization will be examined by bath application of KN-62, a specific inhibitor of CamKII, during this form of non-associative learning.


Other references

Althaus, I.W.; Chou, J.J.; Gonzales, A.J.; Deibel, M.R.; Chou, K.C.en; Kezdy, F.J.; Romero, D.L.; Thomas, R.C.; Aristoff, P.A., 1994: Kinetic studies with the non-nucleoside human immunodeficiency virus type-1 reverse transcriptase inhibitor U-90152E. The bisheteroarylpiperazine U-90152E is a potent inhibitor of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) and possesses excellent anti-HIV activity in HIV-1-infected lymphocytes grown in tissue culture. The compound inhi...

Wu, C.; Olivera, G.H.; Jeraj, R.; Keller, H.; Mackie, T.R., 2003: Treatment plan modification using voxel-based weighting factors/dose prescription. Under various clinical situations, it is desirable to modify the original treatment plan to better suit the clinical goals. In this work, a method to help physicians modify treatment plans based on their clinical preferences is proposed. The metho...

Teply, M.; Obermaier, O.; Havelka, J., 1983: Production of pure dairy starters in Czechoslovakia. Methods used in Czechoslovakia in the production of dairy starters are outlined and recent developments and research in this field relating particularly to the production of frozen concentrates (pelleted or in pieces), use of genetic engineering a...

Verrier M.C., 1985: Alterations in h reflex magnitude by variations in baseline electromyograph excitability. The effect of systematic variations in the baseline level of electromyographic [EMG] activity of the flexor carpi radialis muscle on the magnitude of its H reflex was studied in 4 normal subjects. H reflex magnitude increases with variances in the...

Pessi, A.; Barbato, G.; Ingallinella, P.; Hurni, W.H.; Miller, M.D.; Ciliberto, G.; Cortese, R.; Bazzo, R.; Shiver, J.W.; Bianchi, E., 2003: Structural analysis of the epitope of the anti-HIV MAB 2F5 sheds light into its mechanism of neutralization and HIV fusion. Biopolymers 71(3): 299-300

Sterlini, F.; Hulscher, S.J.M.H.; Hanes, D.M., 2009: Simulating and understanding sand wave variation; a case study of the Golden Gate sand waves. Journal of Geophysical Research 114.F2

Vaccari, A.; Carnelli, V.; Sereni, F., 1968: Treatment of rachitic tetany: controlled experiment with various combinations of vitamin D2, intravenous calcium infusions and parathyroid hormone. Pediatrie 23(1): 47-56

Young Keith, 1970: Gondwanaland and the developing nations. Evaluation of populations and national incomes versus deposits of fossil fuels and soil conditions.

Marshak, J.; Patel, A.M.; Friedel, D.M.; Merchant, P., 2013: Image of the month: superior mesenteric artery syndrome. American Journal of Gastroenterology 108(10): 1556-1556

Globerson, A., 2001: Biogerontology research in Israel. The article describes the special features of gerontology research that has been expanding for five decades in Israel, and outlines the research in the biology of aging, covering a wide spectrum of areas and topics. A variety of associations, inst...