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Treatment with alemtuzumab in a case of refractory primary cutaneous CD30-negative CD8-positive cytotoxic large T-cell lymphoma


, : Treatment with alemtuzumab in a case of refractory primary cutaneous CD30-negative CD8-positive cytotoxic large T-cell lymphoma. European Journal of Haematology 72(5): 377-378

Type 3 hemochromatosis is a rare autosomal recessive disorder due to mutations of the TFR2 gene. We describe clinical, biochemical and histopathologic findings of a patient with type 3 hemochromatosis at presentation and during a follow-up of more than 20 yr and we evaluate the effect of an associated beta-thalassemia trait on phenotypic expression. At the age of 33 yr the patient showed a marked iron overload and severe iron-related complications. After removal of 26 g of iron by subcutaneous deferoxamine infusion a marked clinical improvement was observed. Liver biopsies, performed at the age of 34 and 49 yr, indicate that in type 3 hemochromatosis there is a progressive hepatocellular iron accumulation from Rappaport's zone 1-3 and that iron loading in sinusoidal and portal macrophages occurs only in the more advanced stage. As observed in HFE hemochromatosis, the beta-thalassemia trait seems to aggravate the clinical picture of patients lacking TFR2, favoring higher rates of iron accumulation probably by activation of the erythroid iron regulator.

US$19.90

PMID: 15059077

DOI: 10.1111/j.1600-0609.2004.00232.x


Other references

Keaton, M.; Haney, D.; Andersen, C Brannon, 2005: Impact of drought upon fish assemblage structure in two South Carolina Piedmont streams. The effects of drought on fish assemblages were studied in the Indian Creek (228 kin 2) and Kings Creek (46 km2) watersheds located in the Piedmont Province of South Carolina. Water and fish samples were collected at 13 localities during drought c...

Thery, A., 1934: Etudes sur les Buprestides (quatrieme partie). Bulletin et Annales de la Societe Entomologique de Belgique, 74: 131-151

Mourant, A.E., 1957: Rh notation. British Medical Journal 2(5042): 461-464

Anonymous, 1991: Abstracts of papers presented at XXXIII annual meeting of Japan Society of Smooth Muscle Research (I). Journal of Smooth Muscle Research 27(4): 155-269

Almeida, FB.; Santos, EI., 1973: Triatomineos da Amazonia 2. Acta amazon, 33: 51-52

Fuchs, N., 2002: The Nu-Pro 2000 (Alltech Inc.) - an alternative to animal origin protein. A short review. The protein additive Nu-Pro 2000, obtained from genetically unmodified yeast, was described as containing 6-7% nucleotides, 50-55% crude protein, 30% free amino acids, 30% peptides, vitamins and minerals. Growth performance and fee...

Wit, E.; McClure, J., 2003: Statistical adjustment of signal censoring in gene expression experiments. Motivation: Numerical output of spotted microarrays displays censoring of pixel intensities at some software dependent threshold. This reduces the quality of gene expression data, because it seriously violates the linearity of expression with resp...

Ziehen, T., 1900: Ueber die Pyramidenkreuzung des Schafes. Anatomischer Anzeiger, XVII 237-247

Clarke A.J.; Dupont C., 1992: O acetylated peptidoglycan its occurrence pathobiological significance and biosynthesis. Bacterial cell walls and their structural units, particularly peptidoglycan, induce a vast variety of biological effects in host organisms. The pathobiological effects of peptidoglycan are greatly enhanced by various modifications and substitution...

Anonymous, 1951: Coordination of plans in Soviet hospitals. Zdravotnicka Revue; Vestnik Ministerstva Zdravotnictvi 26(3-4): 82-84