geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Variable expression of activation-linked surface antigens on human mast cells in health and disease


, : Variable expression of activation-linked surface antigens on human mast cells in health and disease. Immunological Reviews 179: 74-81

Mast cells (MC) are multipotent effector cells of the immune system. They contain an array of biologically active mediator substances in their granules. MC also express a number of functionally important cell surface antigens, including stem cell factor receptor (SCFR=kit=CD117), high affinity IgER (FcepsilonRI), or CSaR (CD88). Respective ligands can induce or promote degranulation, migration, or cytokine production. Other integral surface molecules can mediate adhesion or cell aggregation. Recent data suggest that a number of critical molecules are variably expressed on the surface of human MC. In fact, depending on the environment (organ), stage of cell maturation, type of disease, and other factors, MC express variable amounts of activation-linked antigens (CD25, CD63, CD69, CD88), cell recognition molecules (CD2, CD11, CD18, CD50, CD54), or cytokine receptors. At present, however, little is known about the mechanisms and regulation of expression of such antigens. The present article gives an overview of MC phenotypes in health and disease, and attempts to provide explanations for the phenotypic variability of MC.

US$19.90

PMID: 11292030

DOI: 10.1034/j.1600-065x.2001.790108.x


Other references

Taylor, P.D.; Attwood, T.K.; Flower, D.R., 2003: BPROMPT: A consensus server for membrane protein prediction. Protein structure prediction is a cornerstone of bioinformatics research. Membrane proteins require their own prediction methods due to their intrinsically different composition. A variety of tools exist for topology prediction of membrane protein...

Izutsu, K-Ichi.; Fujimaki, Y.; Kuwabara, A.; Aoyagi, N., 2005: Effect of counterions on the physical properties of l-arginine in frozen solutions and freeze-dried solids. The objective of this study was to elucidate the physical properties Of L-arginine and various counterion combinations in frozen aqueous solutions and in freeze-dried solids. L-Arginine remains amorphous in the highly concentrated non-ice phase in...

Davis, P.L.; Hofmann, R.C., 1973: Reduction of chilling injury of citrus fruits in cold storage by intermittent warming. Intermittent warming of Marsh grapefruit in cold storage reduced the incidence of pitting and brown staining, two symptoms of chilling injury. One-week intervals of warming at 70 deg F for 1 day (8 h) were more beneficial than warming at 2-week in...

Orticio, L.P.; Swan, J., 1992: Implementation of the postdischarge follow-up call in the patient care units. The Telephone Call Back System was implemented from October 1989 in the Inpatient and Ambulatory Care Units as a postdischarge follow-up and as an evaluation of the patients' hospital experience. Nurses called patients discharged from the Amb...

Davidenko, J.; Delmar, M.; Oates, R.; Jalife, J., 1986: Electrophysiological actions of dantrolene sodium in isolated sinoatrial and atrioventricular nodes and in a model of ischemia. Recent experiments have suggested that the electrophysiological actions of dantrolene sodium in cardiac tissues may be mediated in part by slow inward current blockade. The authors report here the effects of this agent in tissues the electrical ac...

Margreiter, R.; Hardy, J., 2006: Chimpanzee heart was not rejected by human recipient. Texas Heart Institute Journal 33(3): 412-412

Seth Smith, D., 1927: The Blue-breasted roller. Avicult Mag 5(2): 25-26

Chapman, I.; Kwun, C.; Vargha, Z., 1961: Utilization of aortic knob calcification for radiographic localization. In as much as a previous anatomic study (1) demonstrated that the calcification seen in the lowermost segment of the aortic knob is at the site of the aortic attachment of the ligamentum arteriosum and that the calcification of the upper segment o...

Gvarc, R., 1968: Morphological changes of larvae of Mullerius capillaris in the intermediate host Cepaea vindobonensis (A contribution to the study of the development of Mullerius capillaris in the intermediate host. ). Biologia, Bratisl3: 569-581

Hayano, S.; Uchigasaki, S., 1958: Diaphoraselike enzyme in culture filtrate of Clostridium perfringens BP6K. Japanese Journal of Microbiology 2(1): 39-46