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Comparative inhibitory activity of the stilbenes resveratrol and oxyresveratrol on African swine fever virus replication


, : Comparative inhibitory activity of the stilbenes resveratrol and oxyresveratrol on African swine fever virus replication. Antiviral Research 91(1): 57-63

Stilbenols are polyphenolic phytoalexins produced by plants in response to biotic or abiotic stress. These compounds have received much attention because of their significant biological effects. One of these is their antiviral action, which has previously been documented for two members of this class, namely resveratrol and oxyresveratrol. Here we tested the antiviral effect of these two compounds on African swine fever virus, the only member of the newly created family Asfarviridae and a serious limitation to porcine production worldwide. Our results show a potent, dose-dependent antiviral effect of resveratrol and oxyresveratrol in vitro. Interestingly, this antiviral activity was found for these synthetic compounds and also for oxyresveratrol extracted from new natural sources (mulberry twigs). The antiviral effect of these two drugs was demonstrated at concentrations that do not induce cytotoxicity in cultured cells. Moreover, these antivirals achieved a 98-100% reduction in viral titers. Both compounds allowed early protein synthesis but inhibited viral DNA replication, late viral protein synthesis and viral factory formation.

US$19.90

PMID: 21557969

DOI: 10.1016/j.antiviral.2011.04.013


Other references

Rosas, G.; Ramos, M.A.geles.; Valdecasas, A.G.rcia., 1992: Invertebrates from Spain protected by international conventions Invertebrados espanoles protegidos por convenios internacionales. Unknown

Cerca, M.; Carreon-Freyre, D.C.; Gutierrez, R., 2010: Instability of the urbanized flank of El Penon del Marques volcanic edifice and its relation to land subsidence in Mexico City. We integrate the available information, field cartography, measurement of physical attributes of materials, and Ground Penetrating Radar (GPR) profiles, to obtain a high definition image of the sliding flanks of the Penon del Marques volcanic edif...

Mccreight, Jd, 1998: Dedication: Edward J. Ryder lettuce breeder and geneticist. Plant breeding reviews6(16): 1-14

Pendleton, C.; Jallo, G.I.; Quiñones-Hinojosa, A., 2013: Early multimodality treatment of intracranial abscesses. The treatment of brain abscesses remains one of the success stories of contemporary neurosurgery; what began as a nearly uniformly fatal disease at the turn of the 20th century has become a largely curable ailment through the use of operative and...

Haseler, L.J.; Lin, A.P.; Greene, D.R.; Richardson, R.S., 2001: Incomplete restoration of PCr following exercise relates to degree of ischemia. Medicine & Science in Sports & Exercise 33(5 Supplement): S327, May

Hall, C.A.; Cleveland, C.J., 1981: Petroleum drilling and production in the United States: yield per effort and net energy analysis. For the past three decades the quantity of petroleum (both oil and oil plus gas) found per foot of drilling effort in the United States for any given year can be expressed as a secular decrease of about 2 percent per year combined with an inverse...

Fujii, N.; Abla, D.; Kudo, N.; Hihara, S.; Okanoya, K.; Iriki, A., 2007: Prefrontal activity during koh-do incense discrimination. Whenever we make reasoned decisions we must refer to relevant knowledge obtained through past experience. Our brains test multiple premises and select whichever conclusion serves as the best explanation of the current conditions. In the present st...

D.S.et, F.; Herregoldts, J.; Schots, J.; Deconinck, P.; Van D.V.lde, A.; Van D.V.lde, R.; Lauwers, S., 1998: Implementation and evaluation of procedure specific standards for antibiotic prophylaxis in surgery. Journal of Hospital Infection 40(SUPPL A): P22118, Sept

Cotter R.D.; Rogers J.E., 1961: Exploratory drilling for ground water in the Mountain Iron-Virginia area, Saint Louis County, Minnesota. The Mountain Iron-Virginia area is a broad, SW.-trending valley in the central part of the Mesabi Range. The valley, which heads in the Laurentian Divide and covers about 120 sq. mi., coincides approximately with a bedrock valley filled with as mu...

Dolingo A.I.; Avaryaskin G.A., 1971: Diagnosis and aid in liver traumas. Zdravookhranenie Turkmenistana 15(11): 22-23