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Biologic markers determine both the risk and the timing of recurrence in breast cancer


, : Biologic markers determine both the risk and the timing of recurrence in breast cancer. Breast Cancer Research and Treatment 129(2): 607-616

Breast cancer has a long natural history. Established and emerging biologic markers address overall risk but not necessarily timing of recurrence. 346 adjuvant naïve breast cancer cases from Guy's Hospital with 23 years minimum follow-up and archival blocks were recut and reassessed for hormone-receptors (HR), HER2-receptor and grade. Disease-specific survival (DSS) was analyzed by recursive partitioning. To validate insights from this analysis, gene-signatures (proliferative and HR-negative) were evaluated for their ability to predict early versus late metastatic risk in 683 node-negative, adjuvant naïve breast cancers annotated with expression microarray data. Risk partitioning showed that adjuvant naïve node-negative outcome risk was primarily partitioned by tumor receptor status and grade but not tumor size. HR-positive and HER2-negative (HRpos) risk was partitioned by tumor grade; low grade cases have very low early risk but a 20% fall-off in DSS 10 or more years after diagnosis. Higher grade HRpos cases have risk over >20 years. Triple-negative (Tneg) and HER2-positive (HER2pos) cases DSS events occurred primarily within the first 5 years. Among node-positive cases, only low grade conferred late risk, suggesting that proliferative gene signatures that identify proliferation would be important for predicting early but not late recurrence. Using pooled data from four publicly available data sets for node-negative tumors annotated with gene expression and outcome data, we evaluated four prognostic gene signatures: two proliferation-based and two immune function-based. Tumor proliferative capacity predicted early but not late metastatic risk for HRpos cases. The immune function or HRneg specific signatures predicted only early metastatic risk in Tneg and HER2pos cases. Breast cancer prognostic signatures need to inform both risk and timing of metastatic events and may best be applied within subsets. Current signatures predict for outcome risk within 5 years of diagnosis. Predictors of late risk for HR positive disease are needed.

US$19.90

PMID: 21597921

DOI: 10.1007/s10549-011-1564-5


Other references

Prevoo, M.; Van Riel, P.; Van't Hof, M.; Van Rijswijk, M.; Van Leeuwen, M.; Kuper, I.; Van D.P.tte, L., 1992: The influence of grading and weighting on joint indices. Arthritis & Rheumatism 35(9 SUPPL ): S101

Dittmer, N.T.; Raikhel, A.S., 1997: Analysis of the mosquito lysosomal aspartic protease gene: an insect housekeeping gene with fat body-enhanced expression. In the fat body of insects with cyclic egg maturation, lysosomes play a critical role in the termination of vitellogenesis by selectively degrading the secretory machinery involved in the massive production of yolk protein precursors. To investiga...

Kral, R., 1983: Brassicaceae: Leavenworthia crassa Rollins var. crassa. Technical ication R8 TP USDA Forest Service Southern Region: (2,pt1) 492-494

Noda K.; Yajima A.; Higashiiwai H.; Sai Y., 1971: Keeping of vesical and rectal functions after radical operation of uterine cervical cancer. J Coll Sci Teach 9: 79

Zhang, Z.Xin.; Liu, Y.Ke.; Pan, H.; Pan, L.; Zhang, Q.; Su, H.Min.; Zhao, Q.Ling.; Li, H.; He, C., 2012: The effect of polyethylene glycol recombinant human growth hormone on growth and glucose metabolism in hypophysectomized rats. Hypophysectomy was performed in juvenile rats to build the animal model of GH deficiency. The hypophysectomized animals were randomly assigned into three groups and treated with saline (negative control, n<hsp sp=".12"/>=<hsp sp...

Centers For Disease Control And Prevention, 2002: West Nile virus activity United States, August 15-21, 2002. Morbidity & Mortality Weekly Report. 51(33): 742-743, Ust 23

Czub, E., 1969: The castration of the boar with closure of the wound by clamps. (Brief clinical report). Deutsche Tierarztliche Wochenschrift 76(16): 433-434

Druzhinin, A.D., 1976: New data on fish of the family sciaenidae argyrosomus marleyi. Morphological characteristics for A. marleyi are compared to those established by Norman in 1922. Growth rate and nutrition are discussed.

Brown, V.I.; Hetrick, J.E.; Greene, M.I., 1993: Adaptive and nonadaptive immunity to tumors An introduction to tumor immunology. Mitchell, M S Biological approaches to cancer treatment: Biomodulation : 3-26

Yoneda, T.; Kato, I.; Bonewald, L.F.; Burgess, W.H.; Mundy, G.R., 1993: A novel cytokine with osteoclastopoietic activity. Journal of Periodontal Research 28(6 Pt 2): 521-522