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NVA237, a long-acting muscarinic antagonist, as an emerging therapy for chronic obstructive pulmonary disease


, : NVA237, a long-acting muscarinic antagonist, as an emerging therapy for chronic obstructive pulmonary disease. Therapeutic Advances in Respiratory Disease 5(3): 163-173

Bronchodilation with a long-acting muscarinic antagonist (LAMA) or long-acting β2-agonist is central to the management of chronic obstructive pulmonary disease (COPD). Tiotropium, the first LAMA available for use in COPD, has been shown to be an effective bronchodilator and is generally safe and well tolerated. However, tiotropium has limitations that include a high incidence of dry mouth, slow onset of action and, in some studies, a part of the patient population did not achieve clinically significant bronchodilation. It also remains unclear whether tiotropium reduces progressive deterioration of lung function in patients with COPD. An ideal LAMA would provide clinically meaningful bronchodilation, deliver symptom relief, prevent disease progression, improve exercise tolerance and health status, prevent and treat complications and exacerbations and reduce mortality risk. A 24-h duration of action, rapid onset of action and a good safety and tolerability profile are also desirable. The once-daily LAMA, NVA237 (glycopyrronium bromide), may meet some of these characteristics. NVA237 has high selectivity for the muscarinic type-3 (M3) receptor which might potentially result in a higher therapeutic index than tiotropium, which is less selective for M3. Phase II studies showed that NVA237 once daily provides clinically significant 24-h bronchodilation with a rapid onset of action and a favourable safety and tolerability profile. Phase III studies are ongoing that will assess the long-term safety and efficacy of NVA237.

US$19.90

PMID: 21511677

DOI: 10.1177/1753465811406001


Other references

Wanamaker, Alan D., 2012: Proxy indicators of the surface Atlantic meridional overturning circulation strength during Recent millennia; a need for proxy/model comparisons. Instrumental series of Gulf Stream/North Atlantic Current and Atlantic meridional overturning circulation (AMOC) dynamics are limited to a few decades, hence geological proxy archives are needed to elucidate the past behavior of these systems. In...

Large, M.; Nielssen, O.; Lackersteen, S.; Smith, G., 2010: The associations between infant homicide, homicide, and suicide rates: an analysis of world health organization and centers for disease control statistics. Previous studies have found that rates of homicide of children aged under one (infant homicide) are associated with rates of suicide, but not with rates of homicide. Linear regression was used to examine associations among infant homicide, homicid...

Dibya, D.; Sander, S.; Smith, E.A., 2010: Identifying cytoplasmic proteins that affect receptor clustering using fluorescence resonance energy transfer and RNA interference. Unraveling the complex, dynamic organization of the cell membrane can provide vital information about many aspects of cellular functions. Reported herein is a method for identifying cytoplasmic proteins that affect cell membrane protein organizati...

Hernández Galve, A.; Talamante Serrulla, S.; Sáiz Sánchez, C.; Sabater Pons, A.; Corella Piquer, D., 1991: Trends in kidney cancer mortality in Spain (1951-1985) and review of hospital case histories. The present study is a descriptive epidemiological study of the mortality trends for renal cancer based on the data available for the period spanning 1951 to 1985. The specific death rates show a rising trend that is more marked in males than in f...

Stafa, Z.; Cizek, J., 2005: Quantitative traits of perennial ryegrass (Lolium perenne L.) cultivars in comparison to introduced cultivars. Results are presented of a comparative study on perennial ryegrass cultivars in Croatia and introduced cultivars evaluated in terms of seed production, seed germination, straw yield and herbage mass yield.

Delgado, C.L., 1992: Cereals protection within the broader regional context of agricultural trade problems affecting the Sahel. This paper addresses three sets of issues. Firstly, the case for protecting Sahelian cereals markets from non-African imports is made with reference to the historical context in which such proposals arose. This identifies some key assumptions unde...

Seifert, J.; Ring, J.; Patzelt, E.; Lob, G.; Probst, J.; Brendel, W., 1975: Oral vaccine therapy in chronic osteomyelitis. Hefte Zur Unfallheilkunde: 353-354

Rouby, J.J., 1996: Histology and microbiology of ventilator-associated pneumonias. A good knowledge of histological and bacteriological characteristics of experimental and human ventilator-associated bronchopneumonias (BPN) is of critical importance for the intensivist. BPN can be experimentally produced by intratracheal inocula...

Hiraishi A., 1989: Occurrence of menaquinone as the sole isoprenoid quinone in the photosynthetic bacterium heliobacterium chlorum. Thin-layer chromatography, ultraviolet spectrophotometry, high-performance liquid chromatography, and mass spectroscopy revealed that Heliobacterium chlorum contained menaquinone as the sole quinone with an average amount of 0.35 .mu.mol per g dry...

Kantardjiev V.T.; Veljanov D.K., 1982: The interactions of r forms and s forms of pseudomonas pseudomallei with cell cultures. Dokladi na B"lgarskata Akademiya na Naukite 35(2): 207-210