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Hepatitis C virus infected females have a higher risk of advanced fibrosis and graft loss after liver transplantation than males


, : Hepatitis C virus infected females have a higher risk of advanced fibrosis and graft loss after liver transplantation than males.

In natural history studies of hepatitis C virus (HCV) infection, women have a lower risk of disease progression to cirrhosis. Whether gender influences outcomes of HCV in the post-transplant setting is unknown. All patients transplanted for HCV-related liver disease from 22-27 at 5 U.S. transplant centers were included. The primary outcome was development of advanced disease, defined as biopsy-proven bridging fibrosis or cirrhosis. Secondary outcomes included death, graft loss, and graft loss with advanced recurrent disease. 1,264 patients were followed for a median of 3. years (IQR 1.8-4.7) 34 (24%) were female. The cumulative rate of advanced disease at 3-years was 38% for females and 33% for males (p=.31) but after adjustment for recipient age, donor age, donor anti-HCV positivity, post-transplant HCV treatment, cytomegalovirus infection and center, female gender was an independent predictor of advanced recurrent disease (HR, 1.31; 95%CI, 1.2-1.7; p=.4). Among women, older donor age and treated acute rejection were the primary predictors of advanced disease. The unadjusted cumulative 3 year rates of patient and graft survival were numerically lower in females than males, 75% vs. 8% and 74% vs. 78%, and in multivariable analyses, female gender was an independent predictor for death (HR, 1.3; 95%CI, 1.1-1.67; p=.4) and graft loss (HR, 1.31; 95%CI, 1.2-1.67; p=.3).Female gender represents an under-recognized risk factor for advanced recurrent HCV disease and graft loss. Further studies are needed to determine whether modification of donor factors, immunosuppression, and post-transplant therapeutics can equalize HCV-specific outcomes in women and men.

US$19.90

DOI: 10.1002/hep.24390


Other references

Vahabzadeh, A.; Wittenauer, J.; Carr, E., 2012: Stigma, schizophrenia and the media: exploring changes in the reporting of schizophrenia in major U.S. newspapers. Newspaper media are a major source of information about mental illness in the United States. Previous research has shown that some printed material has been both negative and stigmatizing, which can have a detrimental impact on individuals with me...

Nuelle Laurence M.; Shelton Kevin L., 1986: Geologic and geochemical evidence of possible bedded barite deposits in Devonian rocks of the Valley and Ridge Province, Appalachian Mountains. Economic Geology and the Bulletin of the Society of Economic Geologists 81(6): 1408-1430

Dekeuwer, C.; Bateman, S., 2014: Much more than a gene: hereditary breast and ovarian cancer, reproductive choices and family life. This article presents the results of a study that investigates the way in which carriers of a mutation on the BRCA1 or the BRCA2 gene, associated with a high risk of breast and ovarian cancer, make their reproductive decisions. Using semi-structur...

Anonymous, 1973: 14th session of the Genetics Commission of the European Association of Animal Production, Verona, 7th, 8th and 9th October 1972. Short communications. Andersson, J.; Lindhe, B. Optimum use of beef semen in a dual-purpose or dairy breed : 275.Averdunk, G. [Problems of the evaluation of AI bulls in Germany. First contribution on the effect of genetic differences between female contemporaries on th...

Silva, L.P.; Yu, R.; Calmettes, C.; Yang, X.; Moraes, T.F.; Schryvers, A.B.; Schriemer, D.C., 2011: Conserved interaction between transferrin and transferrin-binding proteins from porcine pathogens. Gram-negative porcine pathogens from the Pasteurellaceae family possess a surface receptor complex capable of acquiring iron from porcine transferrin (pTf). This receptor consists of transferrin-binding protein A (TbpA), a transmembrane iron trans...

Kusnawidjaja, K.; Thomas, H.; Dirscherl, W., 1969: Presence of vanillic acid, ferulic acid and caffeic acid in plant foods. Zeitschrift für Ernahrungswissenschaft 9(4): 290-300

Baastrup, P.C., 1968: Supplementary information about lithium treatment of manic-depressive disorders. Acta Psychiatrica Scandinavica. Supplementum 203: 149-152

Innes, N.L., 1970: Effect of seed size on establishment, early growth and yield of upland octton. In a field trial at Namulonge in 1967-9, acid-delinted seed of Albar cv. SATU 65 (1967-8 only) and BPA 67 were left unsorted or sorted for diameter and then for length to obtain the largest seeds, and then sown on 15 June, 15 July or 15 Aug. The a...

Rusten, T.-Erik; Filimonenko, M.; Rodahl, L., M.; Stenmark, H.; Simonsen, A., 2008: ESCRTing autophagic clearance of aggregating proteins. Autophagy has recently been found to play an important role in the degradation of damaged macromolecules, in particular misfolded, aberrant proteins that can disrupt neuronal function and cause neurodegeneration if not removed. Mutations in the En...

Watson, D.J.; Rennie, A.J., 2003: Decisions in postgraduate education: community dental practice. Since its inception, the Community Dental Service has evolved from a child-centred organization to its much wider remit of current times. This article reviews the present role of the CDS, examines the type of people who make up the workforce and c...