geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

CD44/CD7 blockade and anti-CD154/LFA-1 treatment synergistically suppress accelerated rejection and prolong cardiac allograft survival in mice


, : CD44/CD7 blockade and anti-CD154/LFA-1 treatment synergistically suppress accelerated rejection and prolong cardiac allograft survival in mice.

Current treatments that are efficient in controlling effector T cells responses to allografts have limited efficacy on the accelerated rejection mediated by memory T cells. Effective targeting of alloreactive memory T cells may therefore be explored to improve therapeutic approaches towards solving this problem. In this study, we investigated the synergistic effect of CD44/CD7 blockade and anti-CD154/LFA-1 treatment on the accelerated rejection mediated by memory T cells. While CD44/CD7 blockade had limited effects on the alloresponses of effector T cells in vivo, it diminished the expansion of both CD4+ and CD8+ memory T cells in recipients adoptively transferred with donor-sensitized T cells. In combination with anti-CD154/LFA-1 treatment, CD44/CD7 blockade significantly prolonged cardiac allograft survival in adoptive transfer recipients. We demonstrated that treatment with the combination of all four antibodies (anti-CD154/LFA-1/CD44/CD7) inhibited accelerated rejection by markedly suppressing the alloresponses of effector and memory T cells and reducing the number of graft-in?ltration lymphocytes in adoptive transfer recipients. Meanwhile, CD44/CD7 blockade and anti-CD154/LFA-1 treatment synergically enhanced regulatory T cells (Tregs) by increasing the proportion of splenic Tregs and the expression of IL-1 in these recipients. Our findings contribute to the potential design of therapies for accelerated allograft rejection.

US$19.90

PMID: 21707692

DOI: 10.1111/j.1365-3083.2011.02595.x


Other references

Zhordina, K.I.; Sokolov, A.V.; Kadagidze, Z.G.; Molodyk, A.A., 1981: Correlation of the trophoblastic beta 1-globulin and chorionic gonadotropin indices and the clinical course of the disease in uterine chorionepithelioma. Akusherstvo i Ginekologiia: 55-56

L.Taillandier, V., 1985: Part-time physicians in public hospitals. Soins; la Revue de Reference Infirmiere: 43-44

Niederhofer, H., 2013: First preliminary results of an observation of Panax ginseng treatment in patients with autistic disorder. Autism is a pervasive developmental disorder, with impairments in reciprocal social interaction and verbal and nonverbal communication. There is often the need of psychopharmacological intervention in addition to psychobehavioral therapies, but be...

Green, GA.; Morrison, ML., 1983: Nest-site characteristics of sympatric ferruginous and Swainson's hawks. Murrelet, 641: 20-22

Pili-Truc, J.; Mariottini, P.; Ollier, M.; Mas, J.C.; Levy, G., 1993: Is complete automation possible in hemostasis?: Preliminary results of an STA assay. A completely automated hemostasis test system, the STA from Diagnostica Stago (France), was evaluated. The STA demonstrated satisfactory analytical performance together with fully automated multiparametric and selective qualities. The primary test...

Ivonis, I.; Kialina, L.; Khokhlina, E., 1979: Gibberellin-like substances in the needles of the Norway spruce clones with abundant micro-strobilis. Fiziologiia rastenii 26(2): 330-336

Prouty C.E., 1970: Michigan basin, Paleozoic evolutionary development. Abstracts with Programs - Geological Society of America 2(7): 657-658

Svistelin, D.P., 1974: Combination of glomerulo- and pyelonephritis (an experimental study). Arkhiv Patologii 36(10): 43-50

Nairn, K.; Shepherd, G.L.; Edwards, J.R., 1994: D0870, a new triazole agent Activity against experimental cryptococcal meningitis. Abstracts of the Interscience Conference on Antimicrobial Agents & Chemotherapy 34(0): 255

Bozic, D., 1976: The effects of the implement and the depth of stubble tillage on the incidence and dynamics of the weed flora in the second half of summer. In trials on a degraded chernozem soil in 1972/73, ploughing 15-30 cm deep, ploughing 30 cm deep without a mouldboard, ploughing 30 cm deep with a disk plough, rotary cultivation 10 cm deep and disk harrowing 8 cm deep were compared for their effe...