geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Pitavastatin suppresses diethylnitrosamine-induced liver preneoplasms in male C57BL/KsJ-db/db obese mice


, : Pitavastatin suppresses diethylnitrosamine-induced liver preneoplasms in male C57BL/KsJ-db/db obese mice. Bmc Cancer 11: 281-281

Obesity and related metabolic abnormalities, including inflammation and lipid accumulation in the liver, play a role in liver carcinogenesis. Adipocytokine imbalances, such as decreased serum adiponectin levels, are also involved in obesity-related liver tumorigenesis. In the present study, we examined the effects of pitavastatin - a drug used for the treatment of hyperlipidemia - on the development of diethylnitrosamine (DEN)-induced liver preneoplastic lesions in C57BL/KsJ-db/db (db/db) obese mice. Male db/db mice were administered tap water containing 4 ppm DEN for 2 weeks and were subsequently fed a diet containing 1 ppm or 1 ppm pitavastatin for 14 weeks. At sacrifice, feeding with 1 ppm pitavastatin significantly inhibited the development of hepatic premalignant lesions, foci of cellular alteration, as compared to that in the untreated group by inducing apoptosis, but inhibiting cell proliferation. Pitavastatin improved liver steatosis and activated the AMPK-alpha protein in the liver. It also decreased free fatty acid and aminotransferases levels, while increasing adiponectin levels in the serum. The serum levels of tumor necrosis factor (TNF)-alpha and the expression of TNF-alpha and interleukin-6 mRNAs in the liver were decreased by pitavastatin treatment, suggesting attenuation of the chronic inflammation induced by excess fat deposition. Pitavastatin is effective in inhibiting the early phase of obesity-related liver tumorigenesis and, therefore, may be useful in the chemoprevention of liver cancer in obese individuals.

US$19.90

PMID: 21711565

DOI: 10.1186/1471-2407-11-281


Other references

Wubben, J.E.; Albin, D.M.; Gabert, V.M., 2000: Sequential hydrolysis of swine carcass samples and determination of amino acid concentrations using pre-column derivatization with phenyl isothiocyanate. Comparing amino acid (AA) retention levels in pig carcass to true ileal digestible AA intake provides an estimate of the marginal efficiency of AA utilization. Accurate analysis of AA levels in the carcass samples is critical. However, the standar...

Zhang, G.; Presly, O.; White, F.; Oppel, I.M.; Mastalerz, M., 2014: A permanent mesoporous organic cage with an exceptionally high surface area. Recently, porous organic cage crystals have become a real alternative to extended framework materials with high specific surface areas in the desolvated state. Although major progress in this area has been made, the resulting porous compounds are...

Levy, F.M.; Conge, G., 1953: Experimental and spontaneous infection of the frog (Rana esculenta) with Pseudomonas hydrophila. Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales 147(7-8): 589-590

Shevchenko, N.; Riabchun, V., 1980: Labor productivity in hybridization can be increased. Selektsiia i semenovodstvo: (7) 11-13

Jayme, V.; Vidal Cantu, C.G.; Granados, V.; D.S.ntos, F.J.; Fernandez, L.; Villaescusa, L.; Diaz Lanza, A.M., 2002: The analgesic effect of the aqueous extract of Scrophularia scorodonia L and the participation of opiate receptors. Methods & Findings in Experimental & Clinical Pharmacology 24(Suppl A): 142

Burgess, S.; Freitag, D.F.; Khan, H.; Gorman, D.N.; Thompson, S.G., 2015: Using multivariable Mendelian randomization to disentangle the causal effects of lipid fractions. Previous Mendelian randomization studies have suggested that, while low-density lipoprotein cholesterol (LDL-c) and triglycerides are causally implicated in coronary artery disease (CAD) risk, high-density lipoprotein cholesterol (HDL-c) may not b...

Fanning, Carl D., 1962: Distribution of soluble salts in a typical salt spot of the lower Rio Grande Valley. The soluble salt concentrations found in a typical salt spot of the Lower Rio Grande Valley change rapidly over short distances. Highest concentrations were found to be associated with dense, permeable subsoils. The preponderance of salts are the...

Martin, E., 1968: Pharmacotherapy, its progress and the problems it poses. Pharmaceutica Acta Helvetiae 43(9): 606-618

Hasaerts, R.; Retif, J., 1964: The Problem Of Abscessed Cerebral Tumors. Acta Neurologica et Psychiatrica Belgica 64: 1013-1022

Kishida, Y.; Hiraoka, T.; Ide, H.; Terada, A.; Nakamura, N., 1967: Studies on acetylenic compounds. 63. Synthesis of ibotenic acid. Chemical & Pharmaceutical Bulletin 15(7): 1025-1031