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A second independent locus within DMRT1 is associated with testicular germ cell tumor susceptibility

, : A second independent locus within DMRT1 is associated with testicular germ cell tumor susceptibility. Human Molecular Genetics 20(15): 3109-3117

Susceptibility to testicular germ cell tumors (TGCT) has a significant heritable component, and genome-wide association studies (GWASs) have identified association with variants in several genes, including KITLG, SPRY4, BAK1, TERT, DMRT1 and ATF7IP. In our GWAS, we genotyped 349 TGCT cases and 919 controls and replicated top hits in an independent set of 439 cases and 96 controls in an attempt to find novel TGCT susceptibility loci. We identified a second marker (rs7424) in the doublesex and mab-3-related transcription factor 1 (DMRT1) gene that is independent of the previously described risk allele (rs755383) at this locus. In combined analysis that mutually conditions on both DMRT1 single nucleotide polymorphism markers, TGCT cases had elevated odds of carriage of the rs7424 major A allele [per-allele odds ratio (OR) = 1.48, 95% confidence interval (CI) 1.23, 1.78; P = 2.52 1–7) of being double homozygotes for the risk (major) alleles at DMRT (rs7424) and KITLG (rs4474514) when compared with men without TGCT. Our findings continue to corroborate that genes influencing male germ cell development and differentiation have emerged as the major players in inherited TGCT susceptibility.


PMID: 21551455

DOI: 10.1093/hmg/ddr207

Other references

Koval'kov, V.F.; Snitkin, N.A., 1990: Embryonal fibroma of the ileum complicated by hemorrhage. Klinicheskaia Khirurgiia: 60-60

Bertkau, Ph., 1890: Das Weibchen einer vierten deutschen Atypus-Art. Sitzungsberichte Ver Rheinland. ; xlvii 76-78

Vikkula M.; Syvanen A.C.; Palotie A.; Peltonen L., 1990: Structural analyses of the type ii collagen allele associated with familial osteoarthrosis. Matrix 10(4): 249

Oiki S.; Ikegawa M.; Okada Y., 1986: Whole cell voltage clamp study of potassium channels in fibroblastic l cells. Cell Structure & Function 11(4): 516

Hornsveld, H.; Garssen, B.; Van-Spiegel, P., 1995: Voluntary hyperventilation: The influence of duration and depth on the development of symptoms. Hyperventilation is considered an important factor in the development of somatic symptoms or even panic attacks, though its role has recently been disputed. Arguments are often based on findings from the so-called Hyperventilation Provocation Test...

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