+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

The mysterious microcircuitry of the cerebellar nuclei

, : The mysterious microcircuitry of the cerebellar nuclei. Journal of Physiology 589(Pt 14): 3441-3457

The microcircuitry of cerebellar cortex and, in particular, the physiology of its main element, the Purkinje neuron, has been extensively investigated and described. However, activity in Purkinje neurons, either as single cells or populations, does not directly mediate the cerebellar effects on the motor effector systems. Rather, the result of the entire cerebellar cortical computation is passed to the relatively small cerebellar nuclei that act as the final, integrative processing unit in the cerebellar circuitry. The nuclei ultimately control the temporal and spatial features of the cerebellar output. Given this key role, it is striking that the internal organization and the connectivity with afferent and efferent pathways in the cerebellar nuclei are rather poorly known. In the present review, we discuss some of the many critical shortcomings in the understanding of cerebellar nuclei microcircuitry: the extent of convergence and divergence of the cerebellar cortical pathway to the various cerebellar nuclei neurons and subareas, the possible (lack of) conservation of the finely-divided topographical organization in the cerebellar cortex at the level of the nuclei, as well as the absence of knowledge of the synaptic circuitry within the cerebellar nuclei. All these issues are important for predicting the pattern-extraction and encoding capabilities of the cerebellar nuclei and, until resolved, theories and models of cerebellar motor control and learning may err considerably.


PMID: 21521761

DOI: 10.1113/jphysiol.2010.201582

Other references

de Bakker, C.M.J.; Altman, A.R.; Tseng, W-Ju.; Tribble, M.Beth.; Li, C.; Chandra, A.; Qin, L.; Liu, X.Sherry., 2015: μCT-based, in vivo dynamic bone histomorphometry allows 3D evaluation of the early responses of bone resorption and formation to PTH and alendronate combination therapy. Current osteoporosis treatments improve bone mass by increasing net bone formation: anti-resorptive drugs such as bisphosphonates block osteoclast activity, while anabolic agents such as parathyroid hormone (PTH) increase bone remodeling, with a g...

Marshall, E., 1989: NSF opens high-speed computer network. Science 243(4887): 22-23

Feig, D.S.; Donovan, L.E.; Corcoy, R.; Murphy, K.E.; Amiel, S.A.; Hunt, K.F.; Asztalos, E.; Barrett, J.F.R.; Sanchez, J.Johanna.; de Leiva, A.; Hod, M.; Jovanovic, L.; Keely, E.; McManus, R.; Hutton, E.K.; Meek, C.L.; Stewart, Z.A.; Wysocki, T.; O'Brien, R.; Ruedy, K.; Kollman, C.; Tomlinson, G.; Murphy, H.R.; Grisoni, J.; Byrne, C.; Davenport, K.; Neoh, S.; Gougeon, C.; Oldford, C.; Young, C.; Green, L.; Rossi, B.; Rogers, H.; Cleave, B.; Strom, M.; Adelantado, J.María.; Isabel Chico, A.;, 2017: Continuous glucose monitoring in pregnant women with type 1 diabetes (CONCEPTT): a multicentre international randomised controlled trial. Pregnant women with type 1 diabetes are a high-risk population who are recommended to strive for optimal glucose control, but neonatal outcomes attributed to maternal hyperglycaemia remain suboptimal. Our aim was to examine the effectiveness of co...

Kusewitt, D.F.; Wagner, J.E.; Harris, P.D., 1977: Klossiella sp. in the kidneys of two bats (Myotis sodalis). Organisms believed to be Klossiella sp. sporonts were seen in histological sections prepared from the kidneys of 2 insectivorous bats (Myotis sodalis) in Missouri, USA. 3 apparent stages of sporogony were encountered. This is believed to be the fi...

Johnson, E.L., 1950: The Frankfort-mandibular plane angle and the facial pattern. American Journal of Orthodontics 36(7): 516-533

Arita H.; Kogo N.; Ichikawa K., 1988: Effects of cisternal administration of acetazolamide on rapid excitation of central chemoreceptors. We evaluated rapid and transient changes in phrenic (PN) and internal intercostal (IIC) activities when 0.5 ml of saline saturated with 100% CO2 was injected into the vertebral artery at the C1 level before and after cisternal administration of ca...

Gardner, J.E., 1989: Decision making for sustainable development: selected approaches to environmental assessment and management. Nine approaches to decision making for environmental assessment planning, and management are reviewed to determine how they support principles of sustainable development. The approaches range from environmental impact assessment to adaptive enviro...

Defrin, R.; Ronat, A.; Ravid, A.; Peretz, C., 2003: Spatial summation of pressure pain: effect of body region. The characteristics of spatial summation of pressure pain are not clear. Pressure pain threshold (PPT) and perceived pressure pain intensity were measured in the hand, painfree back and myofascial trigger points (MTPs) in the back, using three dif...

Baehr, G., 1952: The attitude of medical societies to prepaid group practice. New England Journal of Medicine 247(17): 625-627

Lee J Y.; Djamgoz M.B.A.; Hodos W.; Holden A.L.; Porciatti V., 1992: Life span changes in the visual acuity of the japanese quail. Journal of Physiology (Cambridge) 452: 42P