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Macromolecule content influences proton diffusibility in gliomas

, : Macromolecule content influences proton diffusibility in gliomas. European Radiology 21(12): 2626-2632

Different compositions of the extra cellular matrix with changing concentrations of more or less hydrophilic components like proteins may have a major influence on the diffusion phenomena found in gliomas. 24 patients (14 male / 1 female) with histologically confirmed non necrotic glioma underwent preoperative MRI, including magnetisation transfer (MTR), triple echo T2 weighted (T2W) and diffusion weighted (DWI) sequences. Apparent diffusion coefficient (ADC), quantitative T2 and MTR maps were calculated and regions of interest (ROIs) were placed in the tumour centre (TU) and in the contralateral hemisphere (NWM). Informed consent was obtained. The study was approved by the local ethic comity. Mean values evaluated in the NWM / TU were ( standard deviation); ADC: .78 ( .8)? ?1-3 mm2/s / 1.32 ( .27)? ?1-3 mm2/s, T2: 11.66 ( 12.) ms / 252.11 ( 14.53) ms, MTR: .52 ( .1) / .4 ( .4). The mean value of each parameter correlated highly significant with the others (p?<.1). Our results suggest that macromolecules binding protons in their vicinity are a major determinant of proton diffusivity in brain tumours in addition to other factors such as mechanical barriers like membranes or the size of the extra-cellular space.


PMID: 21761279

DOI: 10.1007/s00330-011-2206-3

Other references

Shields, C.R.; Orton, T.J.; Stuber, C.W., 1983: An outline of general resource needs and procedures for the electrophoretic separation of active enzymes from plant tissue. This outline of procedures for starch and polyacrylamide gel electrophoresis includes a diagram illustrating various banding patterns for hypothetical parents and their F1 and F2s and the appropriate genetic interpretations.

Saier, E.; Grauer, R.C.; Starkey, W.F., 1943: The chromo-genic effect of varying mixtures of androsterone and dehydroisoandrosterone. Crystalline androsterone and dehydroisoandrosterone and varying mixtures of these compounds were studied in order to determine whether they influenced each other chemically when combined. The Neustadt and the Fried-good-Whidden techniques were emp...

Yamairibata, A.; Waganawa, T.; Higashimoriyama, M.; Tomoyori, A.; Shimabukuro, M., 1986: Survey among the couples following childbirth attended by husbands. Josanpu Zasshi 40(8): 686-689

Todd, B., 1994: An ecofeminist look at animal research. Nln Publications: 309-319

Popelka, C.G.; Kleinerman, J., 1977: Diffuse pulmonary ossification. Diffuse pulmonary ossification (DPO) was a complication of "shock lung" after aortic valve replacement in a 52-year-old man. The relationship of DPO to shock lung is discussed. A possible mechanism for this complication is based on the d...

Blume, S.S., 1980: A managerial view of research. Science 207(4426): 48-49

Kobayashi, H.; Minami, S.I.hi; Yamamoto, R.; Masumoto, K.; Yanagita, T.; Uezono, Y.; Tsuchiya, K.; Mohri, M.; Kitamura, K.; Eto, T.; Wada, A., 2000: Adrenomedullin receptors in rat cerebral microvessels. To characterize the sites of action of adrenomedullin (AM) in the cerebral microvasculature, we studied the effect of AM on cyclic AMP (cAMP) level as well as expression of AM and its receptor in the rat cerebral microvessels. The microvessels wer...

Demaria, S.; Formenti, S.C., 2007: Sensors of ionizing radiation effects on the immunological microenvironment of cancer. Purpose: When cancer develops in an immunocompetent host it represents the result of a successful deception of the immune system as to the nature of the danger and the type of response needed to reject the neoplastic tissue. We will briefly review...

Guedes, G.R.; Brondízio, E.S.; Barbieri, A.F.; Anne, R.; Penna-Firme, R.; D'Antona, A.O., 2012: Poverty and Inequality in the Rural Brazilian Amazon: A Multidimensional Approach. This paper analyses poverty and inequality dynamics among smallholders along the Transamazon High-way. We measure changes in poverty and inequality for original settlers and new owners, contrasting income-based with multidimensional indices of wel...

Zehner, C.; Bergert, K.D.; Friedrich, K.; Voigt, H., 1987: Development of the biologic exposure test for electrophilic substances--a rational photometric method for the determination of urinary mercapturic acid excretion. Zeitschrift für die Gesamte Hygiene und Ihre Grenzgebiete 33(12): 634-635