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New antimicrobial agents on the horizon


, : New antimicrobial agents on the horizon. Biochemical Pharmacology 82(11): 1528-1539

Antibiotic resistance issues necessitate the continued discovery and development of new antibacterial agents. Efforts are ongoing in two approaches to find new compounds that are effective against antibiotic-resistant pathogens. These efforts involve modification of existing classes including fluoroquinolones, tetracyclines, aminoglycosides, and β-lactams and identification of inhibitors against previously unexploited antibacterial targets. Examples of both approaches are described here with emphasis on compounds in late pre-clinical or clinical stages of development.

US$19.90

PMID: 21798250

DOI: 10.1016/j.bcp.2011.07.077


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