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The effect of nonsteroidal anti-inflammatory drugs on the equine intestine

, : The effect of nonsteroidal anti-inflammatory drugs on the equine intestine. Equine Veterinary Journal. Supplement: 140-144

Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used in the management of pain and endotoxaemia associated with colic in the horse. While NSAIDs effectively treat the symptoms of colic, there is evidence to suggest that their administration is associated with adverse gastrointestinal effects including right dorsal colitis and inhibition of mucosal barrier healing. Several studies have examined the pathophysiology of NSAID associated effects on the large and small intestine in an effort to avoid these complications and identify effective alternative medications. Differences in the response of the large and small intestines to injury and NSAID treatment have been identified. Flunixin meglumine has been shown in the small intestine to inhibit barrier function recovery and increase permeability to lipopolysaccharide (LPS). A range of NSAIDs has been examined in the small intestine and experimental evidence suggests that those NSAIDs with cyclooxygenase independent anti-inflammatory effects or a COX-2 selective mode of action may offer significant advantages over traditional NSAIDs.


PMID: 21790769

DOI: 10.1111/j.2042-3306.2011.00398.x

Other references

Dintenfass, L., 1972: ESR and aggregation of red cells after addition of fructose or glucose. Effect of ABO blood groups. Medical Journal of Australia 2(8): 425-429

Gailus, S.; Suormala, T.; Malerczyk-Aktas, A.Gül.; Toliat, M.R.; Wittkampf, T.; Stucki, M.; Nürnberg, P.; Fowler, B.; Hennermann, J.B.; Rutsch, F., 2010: A novel mutation in LMBRD1 causes the cblF defect of vitamin B(12) metabolism in a Turkish patient. In the cblF defect of vitamin B(12) (cobalamin) metabolism, cobalamin is trapped in lysosomes. Consequently, cobalamin coenzyme synthesis is blocked, and cofactors for methionine synthase and methylmalonyl-coenzyme A (CoA) mutase are deficient. We...

Yantorno, O.; Mazza, L.; Balatii, A., 1978: Effect of the oxygen supply on the bacterial yield of Brucella abortus strain 19. Revista de medicina veterinaria9(2): 55-62

Caylor, A.W.; DozierW.A.Jr; Pitts, J., 1995: Chemical thinning of surecrop peach with Latron AG-98 surfactant. Hortscience 30(3): 430

Hnilica, P.; Grundas, S., 1992: Density distribution, vitreosity and rheological properties of wheat endosperm. The density distributions were obtained for 2 protein components of the endosperms of 3 varieties of wheat (Triticum aestivum). The measurements were performed on samples of rectangular parallelepiped form by the direct method. The rheological pro...

Bovino, A.; Basso, L.; D.G.acomo, G.; Codacci Pisanelli, M.; Basile, U.;, G., 2004: Haemangiopericytoma of greater omentum. A rare cause of acute abdominal pain. Haemangiopericytoma (HPT) is a rare neoplasm that can occur in any part of the human body. In this report, we describe the case of a patient with sudden severe upper abdominal pain caused by primary HPT in the greater omentum.

Nilsson, R.; Orrenius, S.; Ernster, L., 1964: The TPNH dependent oxidation of Luminol catalyzed by rat liver microsomes. In the absence of hydroxyl acceptor the addition of TPNH to microsomes induces the formation of an active intermediate, capable of reacting with luminol and probably also with unsaturated lipids. The intermediate is evidently not identical with fr...

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Al-Salama, Z.T.; Keating, G.M., 2016: Cabozantinib: A Review in Advanced Renal Cell Carcinoma. NlmCategory="UNASSIGNED">The multiple tyrosine kinase inhibitor (TKI) cabozantinib (Cabometyx™) is approved in the USA for the treatment of patients with advanced renal cell carcinoma (RCC) who have received prior antiangiogenic the...

Vollrath, L.; Schroder, H., 1987: Neuronal properties of mammalian pinealocytes?. Serono Symposia Publications from Raven Press, 13-23 No. 44