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Role of viscosity in influencing the glass-forming ability of organic molecules from the undercooled melt state


, : Role of viscosity in influencing the glass-forming ability of organic molecules from the undercooled melt state. Pharmaceutical Research 29(1): 271-284

Understanding the critical factors governing the crystallization tendency of organic compounds is vital when assessing the feasibility of an amorphous formulation to improve oral bioavailability. The objective of this study was to investigate potential links between viscosity and crystallization tendency for organic compounds from the undercooled melt state. Steady shear rate viscosities of numerous compounds were measured using standard rheometry as a function of temperature through the undercooled melt regime. Data for each compound were fit to the Vogel-Tamman-Fulcher (VTF) equation; kinetic fragility via strength parameter (D) was determined. Compounds with high crystallization tendencies exhibited lower melt viscosities than compounds with low crystallization tendencies. A correlation was observed between rate of change in viscosity with temperature and crystallization tendency, with slowly crystallizing compounds exhibiting larger increases in viscosity as temperature decreased below Tm. Calculated strength parameters indicated all compounds were kinetically fragile liquids; thus, kinetic fragility may not accurately assess glass-forming ability from undercooled melt state. A link was observed between the viscosity of a compound through the undercooled melt regime and its resultant crystallization tendency, indicating viscosity is a critical parameter to fully understand crystallization tendency of organic compounds.

US$19.90

PMID: 21786040

DOI: 10.1007/s11095-011-0540-4


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Mason, P., 1997: Tourism codes of conduct in the Arctic and sub-Arctic region. This article investigates the nature and use of tourism codes of conduct in the Arctic and sub-Arctic region within the context of the Arctic Environmental Protection Strategy and the recently created Arctic Council. The article also considers tou...

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Wilson, W.R.; Toomey, J.M., 1974: Our heritage of words in otolaryngology. Eye, Ear, Nose & Throat Monthly 53(1): 4-10

Moriwaki Kiichi; Shiraishi Kazuyuki; Iwata Shuji; Kojima Satoru; Suzuki Akira; Terai Kei; Yamada Seiichi; Sano Masashi, 1985: Report on the geological, geomorphological and geodetic field work in the Soer Rondane Mountains, 1985 (JARE-26). Nankyoku Shiryo = Antarctic Record 86: 36-107

Buhain W.J.; Rammohan G.; Berger H.W., 1975: Pulmonary function in morquios disease a study of 2 siblings. Chest 68(1): 41-45

Slozhenikina L.V.; Fialkovskaya L.A.; Ushakova T.E.; Kuzin A.M., 1991: On the possible participation of the camp system in activation of ornithine decarboxylase in rat tissues after nonlethal fractionated gamma irradiation. A study was made of the activity of adenylate cyclase and cAMP-phosphodiesterase in rat thymus and liver various time intervals following nonlethal fractionated .gamma.-irradiation (2 Gy three times at a week interval). There was a positive correl...

Roumy, M.L.itner, L., 1973: Afferent activities coming from the upper beak of the domestic chicken. Comptes rendus hebdomadaires des seances Serie D Sciences naturelles: 277 (17) 1791-1794

Myers, Pg, 1983: Abandoned coal-mined land reclaimed in 20 states Remarks by Peter G. Myers, Chief of the USDAs Soil Conservation Service. Major news releases and speeches United States Department of Agriculture Office of Governmental and Public Affairs: 11, 17