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A Synthetic Peptide Derived from NK-Lysin with Activity Against Mycobacterium tuberculosis and its Structure–Function Relationship

, : A Synthetic Peptide Derived from NK-Lysin with Activity Against Mycobacterium tuberculosis and its Structure–Function Relationship. International Journal of Peptide Research and Therapeutics 17(4): 301-306

As appearance of drug resistant and multidrug resistant strains of Mycobacterium tuberculosis, antibiotics were no longer the only way to inhibit M. tuberculosis. It was shown that the porcine peptide NK-lysin is active against various microbes by interacting with microbial membranes. The NK-lysin-derived peptide has been demonstrated to possess stronger effect. Under this motivation, we synthesized a short peptide (N22) derived from an active fragment of NK-lysin an important antimycobaterial domain involving the loop and the ?-helical structure. Furthermore, we studied its stability and biological activity in vitro. The results showed that it inhibited the growth of M. tuberculosis H37Rv and had a low toxicity to human erythrocyte.


DOI: 10.1007/s10989-011-9268-6

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