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Mechanisms of dendritic cell trafficking across the blood-brain barrier

, : Mechanisms of dendritic cell trafficking across the blood-brain barrier. Journal of Neuroimmune Pharmacology 7(1): 74-94

Although the central nervous system (CNS) is considered to be an immunoprivileged site, it is susceptible to a host of autoimmune as well as neuroinflammatory disorders owing to recruitment of immune cells across the blood brain barrier into perivascular and parenchymal spaces. Dendritic cells (DCs), which are involved in both primary and secondary immune responses, are the most potent immune cells in terms of antigen uptake and processing as well as presentation to T cells. In light of the emerging importance of DC traficking into the CNS, these cells represent good candidates for targeted immunotherapy against various neuroinflammatory diseases. This review focuses on potential physiological events and receptor interactions between DCs and the microvascular endothelial cells of the brain as they transmigrate into the CNS during degeneration and injury. A clear understanding of the underlying mechanisms involved in DC migration may advance the development of new therapies that manipulate these mechanistic properties via pharmacologic intervention. Furthermore, therapeutic validation should be in concurrence with the molecular imaging techniques that can detect migration of these cells in vivo. Since the use of noninvasive methods to image migration of DCs into CNS has barely been explored, we highlighted potential molecular imaging techniques to achieve this goal. Overall, information provided will bring this important leukocyte population to the forefront as key players in the immune cascade in the light of the emerging contribution of DCs to CNS health and disease.


PMID: 21822588

DOI: 10.1007/s11481-011-9302-7

Other references

Haguenau, F.; Febvre, H.L.; Arnoult, J., 1961: Ultrastructural morphology of Rous sarcoma grown in vitro. Perspectives in Virol 2: 160-173

Atkins, S.D.; Clark, I.M., 2004: Fungal molecular diagnostics: a mini review. Conventional methods to identify fungi have often relied on identification of disease symptoms, isolation and culturing of environmental organisms, and laboratory identification by morphology and biochemical tests. Although these methods are still...

McVay, B.; Talmon, G.A.; Poole, J.A., 2011: Codiagnosis of allergic bronchopulmonary aspergillosis and sarcoid in a severe asthmatic patient. Annals of Allergy, Asthma & Immunology 105(6): 495-496

Hochstaedt, B.; Kahane, E.S., 1980: Blood clotting factors following estrogen therapy. Harefuah 98(7): 295-297

Nepijko, S.A.; Levlev, D.N.; Viduta, L.V.; Schulze, W.; Ertl, G., 2002: The light emission observed from small palladium particles during passage of electronic current. Light emission spectra were measured from separate Pd particles excited by the passage of electrical current through them. As the particle size decreases or input power increases the intensities of peaks increase more strongly in the high-energy p...

Lowyck, B.; Luyten, P.; Corveleyn, J.; D'Hooghe, T.; Buyse, E.; Demyttenaere, K., 2008: Well-being and relationship satisfaction of couples dealing with an in vitro fertilization/ intracytoplasmic sperm injection procedure: a multilevel approach on the role of self-criticism, dependency, and romantic attachment. To extend existing research on the psychological impact of IVF by studying the association between the psychosocial factors of self-criticism and dependency, and romantic attachment, with the well-being and relationship satisfaction of couples acr...

Kimura, N.; Sasano, N., 1986: Hyperplasia of renin-containing cells in a malignant pheochromocytoma: an immunohistochemical and semiquantitative study. The renin-containing cells in the kidneys of a patient with malignant pheochromocytoma were investigated immunohistochemically. Elevated plasma renin and catecholamine levels were detected during the clinical course. Remarkable hyperplasia of reni...

Yuzbasioglu, M.; Kuruuzum-Uz, A.; Guvenalp, Z.; Simon, Aás.; Tóth, Gór.; Harput, U.Sebnem.; Kazaz, C.; Bilgili, B.; Duman, H.; Saracoglu, I.; Demirezer, L.Omur., 2015: Cytotoxic compounds from endemic Arnebia purpurea. Phytochemical studies of the roots and aerial parts of endemic Arnebia purpurea S. Erik & H. Sumbul resulted in the isolation and characterization of four naphthoquinones [isovalerylalkannin (1), α-methyl-n-butanoyl alkannin (2), acetylalkann...

Kawai, T.; Washizuka, M.; Yamauchi, T.; Ishibashi, Y.; Sumi, S.; Kokuho, M., 1987: Clinical analysis and treatment of carcinoma of the prostate with bone metastasis. We carried out a clinical analysis of carcinoma of the prostate with bone metastasis in 141 cases of prostatic cancer treated between 1965 and 1984. Among these, there were 64 cases of stage D, 45.4% and 55 cases of bone metastasis at the first vi...

Rigante, D.; Lopalco, G.; Vitale, A.; Lucherini, O.Maria.; D.C.emente, C.; Caso, F.; Emmi, G.; Costa, L.; Silvestri, E.; Andreozzi, L.; Iannone, F.; Galeazzi, M.; Cantarini, L., 2015: Key facts and hot spots on tumor necrosis factor receptor-associated periodic syndrome. Tumor necrosis factor receptor-associated periodic syndrome (TRAPS), formerly known as familial Hibernian fever, is the most common autosomal dominant autoinflammatory disease, resulting from mutations in the TNFRSF1A gene, encoding the 55-kD tumo...