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Diagnostic accuracy of diffusion-weighted MRI for identifying hepatocellular carcinoma with liver explant correlation

, : Diagnostic accuracy of diffusion-weighted MRI for identifying hepatocellular carcinoma with liver explant correlation. Journal of Medical Imaging and Radiation Oncology 55(4): 362-367

The goal of this study was to use liver explant correlation to assess the diagnostic accuracy of diffusion-weighted (DW)-MRI for hepatocellular carcinoma (HCC). : Thirty-seven patients were retrospectively identified who had undergone liver transplantation and had preoperative, respiratory-triggered, single-shot echo-planar DW-MRI. Two independent blinded observers evaluated the DW-MRI images for HCC and comparison was made with the explanted specimens. By pathology, 29 HCCs (mean largest diameter 2. cm; range .7 4. cm) were identified in 2 patients. Sensitivity and specificity for reader 1 were 55 and 92%, and for reader 2 were 45 and 1%. There was substantial inter-observer agreement (kappa = .64).DW-MR is not sensitive enough for HCC to be used as a stand-alone sequence, although its high specificity suggests that it is likely valuable as a component of a liver MRI protocol.


PMID: 21843170

DOI: 10.1111/j.1754-9485.2011.02286.x

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