+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Emergence of functional spinal delta opioid receptors after chronic ethanol exposure

, : Emergence of functional spinal delta opioid receptors after chronic ethanol exposure. Biological Psychiatry 71(3): 232-238

Delta opioid receptor (DOR) is a promising target to treat multiple indications, including alcoholism, anxiety, and nonmalignant pain. The potential of the DORs has been underappreciated, in part, due to relatively low functional expression of these receptors in na ve states. However, chronic exposure to stress, opioids, and inflammation can induce a redistribution of DORs to the cell surface where they can be activated. Previously, DORs were shown to be selectively/exclusively present in spinal cord circuits mediating mechanical sensitivity but not those mediating thermal nociception under na ve conditions. We spinally administered DOR and mu opioid receptor (MOR) selective agonists ([D-Pen2,D-Pen5]-Enkephalin, deltorphin.


PMID: 21889123

DOI: 10.1016/j.biopsych.2011.07.015

Other references

Arduino, L.J.; Glucksman, M.A., 1962: Lymph node metastases in early carcinoma of the prostate. Journal of Urology 88: 91-93

Williams, L.L.; Hollis, M.D., 1943: Malaria control in the war areas. The policies, scope, organization and operation of the office of Malaria Control in War Areas are discussed.

Cheng J.; M.T.S.; Levy M.N., 1990: The role of the va interval in the atrioventricular nodal wenckebach phenomenon. We induced atrioventricular (AV) nodal Wenckebach periodicity by rapidly pacing the atria in open-chest, anesthetized dogs. The minimum cardiac cycle lengths (AAmin) that permit 1:1 AV conduction were always greater than the basic cardiac cycle le...

Budker, V.G.; Grineva, N.I.; Kovets, N.D.; Lomakina, T.S.; Maev, S.P., 1978: Spatial proximity of the ribosomal mRNA binding center to the 50S subunit. 4-(N-2-chloroethyl-N-methylamino)benzylamide of 5'-heptaadenylic acid was used for affinity labelling of the ribosome in the vicinity of its mRNA-binding centre. This derivative, similar to the free oligonucleotide, stimulates the binding of...

Fukui, M.; Ose, H.; Nakayama, I.; Hosoda, H.; Asano, M.; Kadono, M.; Mogami, S-ichi.; Hasegawa, G.; Yoshikawa, T.; Nakamura, N., 2007: Association between urinary albumin excretion and serum dehydroepiandrosterone sulfate concentrations in women with type 2 diabetes. Phosphoinositide (PI) 3-kinase is involved in insulin-mediated effects on glucose uptake, lipid deposition, and adiponectin secretion from adipocytes. Genetic disruption of the p85alpha regulatory subunit of PI 3-kinase increases insulin sensitivi...

Turkarslan, J., 1988: Identification of sheep and goat mycoplasmas by their biochemical characteristics. Of 34 strains isolated from milk, lungs, synovial fluid, mediastinal lymph nodes, pleural fluid and sent to the laboratory, 31 were identified as Mycoplasma agalactiae and 3 as Mycoplasma mycoides subsp. capri. Examination of nasal, vaginal and ey...

Scott, S., 1927: Two Cases of Cerebellar Abscess: Previously Reported. Proceedings of the Royal Society of Medicine 20(7): 1155-1155

Mitrakas M.G.; Keramidas V.Z.; Tzimourtas C.A., 1991: Nitrate determination in sugar beet sap extracted with lead acetate 2 lead monoxide using an ion selective electrode. Nitrates were directly determined in sugar beet sap, extracted with 0.04 M Pb (CH3COO)2-0.002 M PbO, using an ion-selective electrode. Nitrate levels as low as 5 mg/kg of fresh plant weight could be accurately determined with a high degree of prec...

Haissig, B.E., 1982: Carbohydrate and amino acid concentrations during adventitious root primordium development in Pinus banksiana Lamb. cuttings. Cuttings from 140-day-old seedlings were propagated with and without NAA treatment for 24 days. Needles, upper stems and basal stems (1 cm) were sampled every 3 days and analysed for total soluble amino acids and reducing sugars, sucrose, glucose...

Zimmermann, G.; Wang, L-Ping.; Vaughan, A.G.; Manoli, D.S.; Zhang, F.; Deisseroth, K.; Baker, B.S.; Scott, M.P., 2009: Manipulation of an innate escape response in Drosophila: photoexcitation of acj6 neurons induces the escape response. Plos One 4(4): E5100-E5100