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Emergence of functional spinal delta opioid receptors after chronic ethanol exposure


, : Emergence of functional spinal delta opioid receptors after chronic ethanol exposure. Biological Psychiatry 71(3): 232-238

Delta opioid receptor (DOR) is a promising target to treat multiple indications, including alcoholism, anxiety, and nonmalignant pain. The potential of the DORs has been underappreciated, in part, due to relatively low functional expression of these receptors in na ve states. However, chronic exposure to stress, opioids, and inflammation can induce a redistribution of DORs to the cell surface where they can be activated. Previously, DORs were shown to be selectively/exclusively present in spinal cord circuits mediating mechanical sensitivity but not those mediating thermal nociception under na ve conditions. We spinally administered DOR and mu opioid receptor (MOR) selective agonists ([D-Pen2,D-Pen5]-Enkephalin, deltorphin.

US$19.90

PMID: 21889123

DOI: 10.1016/j.biopsych.2011.07.015


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