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Endogenous retinoids in the hair follicle and sebaceous gland

, : Endogenous retinoids in the hair follicle and sebaceous gland. Biochimica et Biophysica Acta 1821(1): 222-229

Vitamin A and its derivatives (retinoids) are critically important in the development and maintenance of multiple epithelial tissues, including skin, hair, and sebaceous glands, as shown by the detrimental effects of either vitamin A deficiency or toxicity. Thus, precise levels of retinoic acid (RA, active metabolite) are needed. These precise levels of RA are achieved by regulating several steps in the conversion of dietary vitamin A (retinol) to RA and RA catabolism. This review discusses the localization of RA synthesis to specific sites within the hair follicle and sebaceous gland, including their stem cells, during both homeostasis and disease states. Highlights: The pilosebaceous unit consists of a hair follicle and sebaceous gland. The pilosebaceous unit requires precise levels of retinoic acid. Retinoic acid synthesis localized to the pilosebaceous unit, including stem cells. Mechanisms of action of retinoic acid within the pilosebaceous unit are emerging. But much more information has yet to be discovered.


PMID: 21914489

DOI: 10.1016/j.bbalip.2011.08.017

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