geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Endogenous retinoids in the hair follicle and sebaceous gland


, : Endogenous retinoids in the hair follicle and sebaceous gland. Biochimica et Biophysica Acta 1821(1): 222-229

Vitamin A and its derivatives (retinoids) are critically important in the development and maintenance of multiple epithelial tissues, including skin, hair, and sebaceous glands, as shown by the detrimental effects of either vitamin A deficiency or toxicity. Thus, precise levels of retinoic acid (RA, active metabolite) are needed. These precise levels of RA are achieved by regulating several steps in the conversion of dietary vitamin A (retinol) to RA and RA catabolism. This review discusses the localization of RA synthesis to specific sites within the hair follicle and sebaceous gland, including their stem cells, during both homeostasis and disease states. Highlights: The pilosebaceous unit consists of a hair follicle and sebaceous gland. The pilosebaceous unit requires precise levels of retinoic acid. Retinoic acid synthesis localized to the pilosebaceous unit, including stem cells. Mechanisms of action of retinoic acid within the pilosebaceous unit are emerging. But much more information has yet to be discovered.

US$19.90

PMID: 21914489

DOI: 10.1016/j.bbalip.2011.08.017


Other references

Linde, S., 1957: Multivitamin preparations from the galenic point of view. Svensk Farmaceutisk Tidskrift 61(11): 277-288

Tukey, Loren D., 1952: Effect of night temperature on growth of the fruit of the sour cherry. Bearing limbs of Montmorency sour cherry were subjected to several different night temps. in order to study temp. influences on fruit development for the period between full bloom and fruit maturity. Results showed that increase in night temp. acc...

Miller Arnold I.; Holland Steven M.; Droser Mary L.; Patzkowsky Mark E.; Westrop Stephen R.; Adrain Jonathan M., 1998: Dynamics of the Ordovician radiation; discussion and reply. Paleobiology 24(4): 524-528

Kyle Barrett, Stephen T.Samoray, Brian S.Helms and Craig Guyer, 2012: Southern Two-Lined Salamander Diets in Urban and Forested Streams in Western Georgia. Streams are heavily affected by watershed urbanization as increased stormwater runoff changes their physical and chemical composition. Benthic macroinvertebrate species richness has been consistently shown to decline with urbanization. Conversely,...

Figer, A.; Karasik, Y.Patael.; Baruch, R.Gershoni.; Chetrit, A.; Papa, M.Z.; Sade, R.Bruchim.Bar.; Rizel, S.; Friedman, E.; Riezel, S., 2002: Insulin-like growth factor I polymorphism and breast cancer risk in Jewish women. Genes that confer mild or moderate susceptibility to breast cancer may be involved in the pathogenesis of sporadic breast cancer, modifying the phenotypic expression of mutant BRCA1/BRCA2 alleles. An attractive candidate is the insulin-like growth...

Yasuda, M.; Murakami, M.; Muramatsu, T.; Itoh, J.; Saito, K.; Kamoshida, S.; Kajiwara, H.; Osamura, R.Y.shiyuki, 2003: Immunohistochemical expression of type-1 carbohydrate antigens: Availability of DU-PAN-2 on pathological and clinical aspects. Expression of type-1 carbohydrate antigens (CBAs), DU-PAN-2 and CA19-9, was strongly dependent on hormonal regulation during the menstrual cycle in the endometrium. DU-PAN-2 expression was more frequent than that of CA19-9 in endometrial adenocarc...

Matsuoka, M.; Green, P.L., 2009: The HBZ gene, a key player in HTLV-1 pathogenesis. Human T-cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia/lymphoma (ATL) and is also associated with a variety of lymphocyte-mediated diseases. The HTLV-1 basic leucine zipper (HBZ) gene, found to be consistently expressed in ATL, h...

Lamborot, M.; Alvarez, E.; Campos, I.; Espinoza, A., 1981: Karyotypic characterization of three Chilean subspecies of Liolaemus monticola. L. monticola, Mueller and Hellmich, is a highly variable, endemic montane species distributed along the temperate Andes in Chile. The subspecies (Mueller and Hellmich) karyotypes established from their type localities are L. m. villaricensis and L...

King, R.B.; Semik, P.E., 2006: Stroke caregiving: difficult times, resource use, and needs during the first 2 years. Despite high levels of distress among stroke caregivers, research on resource use and unmet needs is limited. The major purposes of this study were to identify the most difficult times, unmet needs, and advice of caregivers during the first 2 year...

Pu, C.F.; Yu, Y.H.ng; Chun, D.R.ng; Yu, X.D., 1995: Comparative studies on photodynamic therapy in two tumor models with sulfonated aluminum phthalocyanines. Photochemistry & Photobiology 61(5 SUPPL ): 83S