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Safety of antipsychotics in people with intellectual disability


, : Safety of antipsychotics in people with intellectual disability. British Journal of Psychiatry 199(4): 289-295

Despite frequent use, little is known about the metabolic and endocrine side-effects of antipsychotics in individuals with intellectual disability. To compare indices of obesity, glucose, lipids and prolactin between antipsychotic-treated and antipsychotic-naive individuals with intellectual disability and also between participants with intellectual disability and controls from the general population.MethodObservational study comparing 138 antipsychotic-treated and 64 antipsychotic-naive participants with intellectual disability in one National Health Service trust with general population controls. Antipsychotic treatment comprised: risperidone 48%, olanzapine 18%, thioxanthenes 1%, other 24%; monotherapy 95% of participants; mean treatment duration 8 years; median daily chlorpromazine equivalent dose 18 mg (range 16–667). Metabolic indices were the same or more favourable in the intellectual disability group than the general population control group but overweight/obesity and type 2 diabetes were more prevalent in the women in the intellectual disability group than the control group. Metabolic indices were similar, statistically or clinically, between the antipsychotic-treated and the antipsychotic-naive groups but there was a non-significant trend towards a higher rate of type 2 diabetes in the antipsychotic group. A total of 1% and 7% of participants on amisulpride/sulpiride and risperidone respectively had hyperprolactinaemia, with secondary hypogonadism in 77% and 4% of affected women and men. Antipsychotics, on average, did not increase metabolic risk, although the existence of a susceptible subgroup at risk of diabetes cannot be excluded. Some antipsychotics induced hyperprolactinaemic hypogonadism, requiring active management. However, our findings suggest that antipsychotics at the low doses routinely prescribed for people with intellectual disability are generally safe in relation to metabolic adverse effects, even if efficacy remains poorly defined.

US$19.90

PMID: 21816867

DOI: 10.1192/bjp.bp.110.085670


Other references

Wood, J.P.; DeSantis, L.; Chao, H.M.; Osborne, N.N., 2001: Topically applied betaxolol attenuates ischaemia-induced effects to the rat retina and stimulates BDNF mRNA. It has previously been reported that the beta1-adrenoceptor antagonist, betaxolol, can protect retinal neurones from ischaemia when applied topically. It has further been shown that betaxolol can reduce influx of both sodium or calcium into neuron...

Swarnkar, C.P.; Sanyal, P.K.; Singh, D.; Khan, F.A.; Bhagwan, P.S., 1999: Comparative disposition kinetics of albendazole in sheep following oral and intraruminal administration. The pharmacokinetics of albendazole was studied in sheep following single oral and intraruminal administration at nematocidal dose rates. The disposition curves of its metabolites indicated increased uptake of the drug in sheep following intrarumi...

Sillerud L.O.; Y.R.K.; Schafer D.E., 1982: Assignment of the carbon 13 nmr spectra of gangliosides g m 4 g m 3 g m 2 g m 1 g d 1a and g t 1b. Complete 13C NMR assignments are presented for gangliosides in the series [chicken brain] Gm4, [bovine adrenal medulla] Gm3, [human Tay Sachs brain]GM2, [bovine brain] GM1, GD1b, and GT1b. The gangliosides studied are related by the sequential add...

Kehlmaier, Christian, 2004: Faunistic and taxonomic notes of Anisopodidae, Acroceridae, Conopidae and Stratiomyidae (Diptera) collected on the Iberian Peninsula. Faunistic records for 35 dipterous species of Anisopodidae, Acroceridae, Conopidae and Stratiomyidae collected at various locations in mainland Spain are presented. Amongst the material, the stratiomyid Adoxomyia dahlii (Meigen, 1830), the conopid...

Tardif, G.; Pivik, J.; Rock, D., 1995: Facilitating collaborative research between consumers and researchers. Clinical & Investigative Medicine 18(4 SUPPL ): B121

Gahrton, G.; Ringdén, O.; Robèrt, K.H., 1988: Bone marrow transplantation--rapid development toward new indications. Nordisk Medicin 103(4): 116-119

Ogushi, M.; Yoshie-Stark, Y.; Suzuki, T., 2006: Apoptosis-inducing activity of hot water extracts from the sea cucumber in human colon tumor cells. To study the anti-tumor activity of sea cucumber extracts, human colon adenocarcinoma Caco-2 cells were exposed to hot water extract of sea cucumber. Morphological changes with apoptotic bodies were observed in the cells treated with the extract....

Sadie, Y., 1995: Affirmative action in South Africa: a gender development approach. The paper focuses on the role of gender development in addressing the position of the most oppressed and disadvantaged sector of South African society, rural African women. Over the past few years affirmative action programmes have been debated, a...

Truksa, J.; Zaborsky, J., 1976: The effect of interrow spacing and density of stand in irrigated plots on maize yield. Under irrigation, the eight hybrids investigated produced higher grain yields the closer the row spacing and the greater the density of stand. The highest-yielding hybrid, TA7476/70, was also the most responsive to these influences. Without irriga...

Graf R.; Schluens J., 1979: Ultrastructural and histochemical investigation of the terminal capillaries in the spleen of the carp cyprinus carpio. In the spleen of the carp arterial capillaries of a highly differentiated structure were studied by light microscopy and EM. These capillaries share various structural characteristics with the sheathed capillaries (ellipsoids of Schweigger-Seidel)...