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The Oxidative Effect of Prolonged CO2Pneumoperitoneum A Comparative Study in Rats

, : The Oxidative Effect of Prolonged CO2Pneumoperitoneum A Comparative Study in Rats.

The current study evaluated the effect of time in the severity of the oxidative stress due to pneumoperitoneum. Forty Wistar rats were allocated randomly into 2 groups. The 1 h pneumoperitoneum (Pp) group, which was subjected to 6 min of pneumoperitoneum, and the 3 h Pp, to pneumoperitoneum for 18 min. The animals were divided in half. One half of the rats were left resting for 3 min after abdominal desufflation and the other for 8 h. After these two time periods, blood, liver, kidney, lung and small intestine were obtained for biochemical analysis and histopathological examination. In the 3 h Pp, the associated oxidative stress was increased. There was an overt increase in blood and tissue MDA and blood PAB values. The MPO values were significantly higher in the 3 h Pp group in serum, kidneys, and intestine during the early phase of reperfusion and in liver after 8 h of reperfusion. These changes occurred in the presence of light microscopic evidence of greater tissue damage for the 3 h Pp, which were consistent with the fluctuation of the MPO values. In our experimental model, we proved biochemically and histologically that time of maintenance of pneumoperitoneum is an additive factor that could cause increased oxidative stress in laparoscopic procedures.


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