geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

A novel fused 1,2,4-triazine aryl derivative as antioxidant and nonselective antagonist of adenosine A2Areceptors in ethanol-activated liver stellate cells


, : A novel fused 1,2,4-triazine aryl derivative as antioxidant and nonselective antagonist of adenosine A2Areceptors in ethanol-activated liver stellate cells.

It has been detected that hepatic adenosine A2Areceptors play an active role in the pathogenesis of hepatic fibrosis and suggest a novel therapeutic target in the treatment and prevention of hepatic cirrhosis. In this paper we examined if our new triazine derivative (IMT) can inhibit ethanol-induced activation of HSCs measured as increased ?-SMA, collagen synthesis and enhanced oxidative stress in rat liver stellate cells. We also investigated its influence on cytokines (TGF-?, TNF-?) synthesis, MMP-2 and TIMP-1 production and ethanol-induced intracellular signal transduction. Moreover, with using of known adenosine A2Areceptor agonist (CGS2168), and antagonist (SCH58261) we examined if this triazine derivative acts on adenosine receptors.We detected a strong antagonistic action of new triazine derivative (IMT) on ethanol-induced rat liver stellate cells activation, observed as a significant decrease in ?-SMA, collagen synthesis, reactive oxygen species production, TGF-?, TNF-?, MMP-2 and TIMP-1 production as well as JNK, p38MAPK, NF?B, I?B, Smad3 phosphorylation. Moreover, IMT strongly inhibited activation of stellate cells by known selective agonist of adenosine A2Areceptor (CGS 2168). When known A2Areceptor antagonist (SCH 58261) was used together with IMT this effect was not spectacular. Additionally, only slight enhancement of inhibition was observed when cells were pretreated both IMT with SCH 58261, hence we suppose that IMT acts as nonselective antagonist of A2Areceptors, and, besides its antioxidant activity, also by this way inhibited ethanol-induced stellate cell activation.Ethanol activates liver stellate cells. Chronic activation of stellate cells leads to liver fibrosis. New triazine derivative inhibit ethanol-induced activation of stellate cells. New triazine derivative acts as nonselective antagonist of A
US$29.90


Other references

Ruegg, Markus A., 2001: Molecules involved in the formation of synaptic connections in muscle and brain. Synapses are highly specialized structures designed to guarantee precise and efficient communication between neurons and their target cells. Molecules of the extracellular matrix have an instructive role in the formation of the neuromuscular junct...

Bayart, F.; Hayashi, K.T.; Faull, K.F.; Barchas, J.D.; Levine, S., 1990: Influence of maternal proximity on behavioral and physiological responses to separation in infant rhesus monkeys (Macaca mulatta). The effects of maternal proximity on the behavioral and physiological responses of infant rhesus macaques during 4 days of total or adjacent separations from the mother were studied. The 6 infants tested showed behavioral responses that differenti...

Mori K., 1975: Neuro physiological basis of anesthesia. International Anesthesiology Clinics 13(1): 1-244

Morel Seytoux, H.J.; Daly, C.J.; Illangasekare, T.; Bazaraa, A., 1981: Design and merit of a river-aquifer model for optimal use of agricultural water. The design of a stream-aquifer model to assess the impact of alternative strategies of management for maximum beneficial agricultural use of water is discussed. The model was successfully applied to a field problem in the South Platte river basin...

Litwin, T.R.; Clarke, M.A.; Dean, M.; Wentzensen, N., 2017: Somatic Host Cell Alterations in HPV Carcinogenesis. High-risk human papilloma virus (HPV) infections cause cancers in different organ sites, most commonly cervical and head and neck cancers. While carcinogenesis is initiated by two viral oncoproteins, E6 and E7, increasing evidence shows the import...

Shimizu, T., 1977: Some additional notes on impatiens balsaminaceae of thailand. Three new species of Impatients (I. hongsonensis, I. larsenii and I. siamensis ) are presented. Morphological descriptions and distribution patterns of these and 5 other species (I. cardiophylla, I. griffithii, I. masoni, I. platypetala and I. vau...

Larimer, M.E.; Kaysen, D.L.; Lee, C.M.; Kilmer, J.R.; Lewis, M.A.; Dillworth, T.; Montoya, H.D.; Neighbors, C., 2009: Evaluating level of specificity of normative referents in relation to personal drinking behavior. Research has found perceived descriptive norms to be one of the strongest predictors of college student drinking, and several intervention approaches have incorporated normative feedback to correct misperceptions of peer drinking behavior. Little...

Luxon, J.T.; Parker, D.E., 1981: Practical spot size definition for single higher-order rectangular-mode laser beams. Applied Optics 20(10): 1728-1729

Vercammen, J., 1997: Chemical thinning should no longer be ignored in our apple culture. The advantages of chemical fruit thinning of apples are discussed, including improved control of biennial bearing, reduction in the time spent on hand thinning and enhanced fruit quality at harvest. Data are included from several trials carried ou...

Li, W-Chun.; Liu, D., 2015: A new species of Metaeuchromius (Lepidoptera, Crambidae) from the Tibetan glacier area of China. Metaeuchromiusglacialis Li, sp. n. is described from the Tibetan glacier area of China. The new species is similar to Metaeuchromiuscirce Bleszynski by the distal projection of costa exceeding the apex of valva, and the phallus with strong spine-l...