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The role of basement membrane in angiogenesis and tumor growth

, : The role of basement membrane in angiogenesis and tumor growth. Pathology, Research and Practice 190(9-10): 854-863

Expansion of the tumor-cell mass is dependent on both the degree of tumor vascularization and the rate of angiogenesis. Blood vessel growth is controlled, in part, by the matrix surrounding it, in particular, the basement membrane underlying the endothelium. Here we illustrate that laminin, a major component of basement membrane, has several biologically active sites that can bind to endothelial and tumor cells, and have the ability to regulate angiogenesis and tumor growth. We show that synthetic peptides at two sites in the laminin B1 chain (the RGD and YIGSR sequences) inhibit angiogenesis, whereas a third site in the A chain, designated SIK-VAV, stimulates vessel and tumor cell growth. By developing strategies that promote or inhibit the activities of these sites in laminin, we may obtain methods to inhibit angiogenesis and subsequent tumor growth.


PMID: 7534913

DOI: 10.1016/S0344-0338(11)80989-1

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Ooi, B.S.; Tjandra, J.J.; Pedersen, J.S.; Bhathal, P.S., 2000: Giant pseudopolyposis in inflammatory bowel disease. Australian and New Zealand Journal of Surgery 70(5): 389-393

Smith E.J.; Kron S.D.; Gross P.R., 1970: Erosive adenomatosis of the nipple. Archives of Dermatology 102(3): 330-332

Parmar, M.S., 2005: Paradise -- not without its plagues: overwhelming Blastomycosis pneumonia after visit to lakeside cottages in Northeastern Ontario. Background: Visiting lakes and cottages is a common leisure activity during summer among most Canadians and paradise for some. Various leisure activities are involved during these visits, including cleaning and 'airing' the cottage after...

Nabarro, J., 1986: Transsphenoidal surgery for Cushing's syndrome. Journal of the Royal Society of Medicine 79(5): 253-254

Anonymous, 2015: Correction. [This corrects the article DOI: 10.7860/JCDR/2013/5704.3613.].

Martinsen, K., 1978: Theory and practice in nursing - and discussions which have been like covers. Sykepleien 65(1): 23-25

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Roldan, E.R.; Fragio, C., 1993: Phospholipase A2 activation and subsequent exocytosis in the Ca2+/ionophore-induced acrosome reaction of ram spermatozoa. In ram spermatozoa treatment with Ca2+ and A23187 or ionomycin stimulated the release of arachidonic acid (20:4) and exocytosis of the acrosome in a time- and concentration-dependent manner. Diacylglycerol did not appear to be the source of 20:4....

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