+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Reduction in mortality in subjects with homozygous familial hypercholesterolemia associated with advances in lipid-lowering therapy

, : Reduction in mortality in subjects with homozygous familial hypercholesterolemia associated with advances in lipid-lowering therapy. Circulation 124(20): 2202-2207

Homozygous familial hypercholesterolemia is an inherited disorder caused by mutations in both low-density lipoprotein receptor alleles, which results in extremely elevated plasma low-density lipoprotein cholesterol concentrations and very early morbidity and mortality due to cardiovascular disease. and Results-To evaluate the impact of advances in lipid-lowering (predominantly statin) therapy on cardiovascular disease morbidity and mortality in a large cohort of patients with homozygous familial hypercholesterolemia, the records of 149 patients (81 females, 68 males) from 2 specialized lipid clinics in South Africa were evaluated retrospectively. Homozygous familial hypercholesterolemia was diagnosed by confirmation of mutations in genes affecting low-density lipoprotein cholesterol or by clinical criteria. A Cox proportional hazard model with time-varying exposure was used to estimate the risk of death and major adverse cardiovascular events among statin-treated patients compared with statin-naive patients. The hazard ratio for benefit from lipid therapy, calculated with the Cox proportional hazards model for the end point of death, was .34 (95% confidence interval .14–.86; P=.2), and for the end point of major adverse cardiovascular events, it was .49 (95% confidence interval .22–1.7; P=.7). This occurred despite a mean reduction in low-density lipoprotein cholesterol of only 26.4% (from 15.9±3.9 to 11.7±3.4 mmol/L; P<.1) with lipid-lowering therapy. -Lipid-lowering therapy is associated with delayed cardiovascular events and prolonged survival in patients with homozygous familial hypercholesterolemia.


PMID: 21986285

DOI: 10.1161/CIRCULATIONAHA.111.042523

Other references

Bateman, C., 2010: Academic health complexes bleeding in 'no man's land'. South African Medical Journal 100(1): 17-19

Berman, E.; Eyal, S.; Marom, E., 2017: Trends in utilization of benzodiazepine and Z-drugs in Israel. Studies on benzodiazepine (BZDs) as well as Zopiclone and Zolpidem (Z-drugs) utilization are important for estimating the prevalence of medical conditions, providing the basis for pharmacovigilance, and identifying temporal trends of consumption....

Acad Nat Med, 1968: Meeting of the academie nationale de medecine national academy of medicine november 19 1968. Presse Medicale 76(47): 2237

Robinson C.D.; Beckwith J.B., 1981: Dimensions of self regard. Items from the Rosenberg Self-Esteem scale, a semantic differential scale of self-concept ratings, and the Spielberger A-trait scale were analyzed using principal factoring with iteration and VARIMAX rotation. Data for the factor analysis were pro...

Reppenhagen, W., 1990: Mammillaria beneckei Ehrenberg and its variety multiceps Reppenhagen. Cactus and succulent journal 62(6): 286-288

Perkins M.; Von Hoff D.D., 1981: Experience with a 2 layer soft agar system for growing gastro intestinal tumors. Stroehlein, J R And M M Romsdahl (Ed ) Gastrointestinal Cancer; 25th Annual Clinical Conference on Cancer, Houston, Tex , Usa, Nov 5-7, 1980 Xviii+474p Raven Press: New York, N Y , Usa Illus P381-390

Hirai, J.; Sasaki, M., 1988: Problems in your nursing: assistance in rehabilitation practiced in bed; support of a patient apprehensive of the clinical course after discharge. Kurinikaru Sutadi 9(13): 1262-1263

Brajtburg, J.; Elberg, S.; Kobayashi, G.S.; Bolard, J., 1994: Amphotericin B incorporated into egg lecithin-bile salt mixed micelles: molecular and cellular aspects relevant to therapeutic efficacy in experimental mycoses. The cellular activities of amphotericin B (AmB) used as Fungizone were compared with those of AmB complexed to either egg lecithin and glycocholate (Egam) or egg lecithin and deoxycholate (Edam). Under conditions in which leakage of K+ from erythr...

Guaragna, G.P.; Cardoso, V.L.; Lobo, R.B.; Barbosa, I. de A., 1988: Inbreeding and reproduction in Mantiqueira cattle at the Pindamonhangaba Experiment Station. The effect of inbreeding on reproductive performance was investigated in 443 Mantiqueira cows, born over a period of 30 yr. The degree of inbreeding of cows in the herd ranged from 0 to 28.32% and averaged 2.88+or-0.22%, and the degree of inbreedi...

Pieters, B.J.; Liess, M., 2005: Maternal nutritional state determines the sensitivity of Daphnia magna offspring to short-term Fenvalerate exposure. Daphnia populations in the field suffer periodic natural stress conditions such as low food levels. It is known that at low nutritional supply, Daphnia produces fewer but larger offspring, which are acutely less sensitive to chemical stress. We hy...