+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Protective effects of melatonin and S-methylisothiourea on mechlorethamine induced nephrotoxicity

, : Protective effects of melatonin and S-methylisothiourea on mechlorethamine induced nephrotoxicity. Journal of Surgical Research 175(1): E17-E23

In this study, we aimed to investigate the protective effects of melatonin (MEL) and S-methylisothiourea (SMT) on mechlorethamine (MEC) induced nephrotoxicity.Materials A total of 36 male Sprague-Dawley rats were divided into four groups: control, MEC, MEC+MEL, and MEC+SMT. Three groups received single dose of MEC (3.5 mg/kg)viatransdermal route. Control animals were given saline only via transdermal route. MEL (1 mg/kg) was administered intraperitoneally 3 min after the application of MEC, and after the same dose of MEL was given every 12 h for a total of six doses. SMT (5 mg/kg) was also given intraperitoneally 3 min after the application of MEC. The tissue TNF-?, IL-1?, and NOx levels were found significantly different for all groups (P< .1). MEC application resulted in severe histopathological changes. Melatonin showed meaningful protection against kidney damage. But protection by SMT was weaker. TNF-? and IL-1? levels increased significantly with MEC application, and MEL and SMT ameliorated these increases in kidney tissue. MEC also elevated NOx levels in kidney tissue. Both inflammation and oxidative stress may have an important role in the MEC induced nephrotoxicity. MEL and SMT may also have anti-inflammatory properties, as well as anti-oxidant properties.


PMID: 22261582

DOI: 10.1016/j.jss.2011.11.002

Other references

Vedernikov, A.N.; Fettinger, J.C.; Mohr, F., 2004: Synthesis and reactivity of dimethyl platinum(IV) hydrides in water. New hydrophilic ligands of the di(2-pyridyl)methanesulfonate family, L = dpms and Me-dpms, enable the synthesis of methyl platinum(IV) hydrides, LPtMe2H, the study of very fast CH reductive coupling, and reductive elimination of these complexes in...

Bogomolov Y.G., 1967: Problems relating to geothermal and hydrogeothermal characteristics of the Siberian platform. Artesian basins, tabulated temperature data, basement depths, permafrost zone.

Horne, G., 2006: Public Health's new direction?. New Zealand Medical Journal 119(1245): U2324-U2324

Jemec, G.B.; Kollerup, G.; Kisling, A.; Serup, J., 1991: Possible influence of growth hormone on sebum excretion in man. Dermatologica 183(1): 54-54

Tseng, H-Wu.; Fan, J.; Kupinski, M.A.; Sainath, P.; Hsieh, J., 2015: Assessing image quality and dose reduction of a new x-ray computed tomography iterative reconstruction algorithm using model observers. A number of different techniques have been developed to reduce radiation dose in x-ray computed tomography (CT) imaging. In this paper, the authors will compare task-based measures of image quality of CT images reconstructed by two algorithms: con...

Lee, J.S.; Nápoles, A.; Mutha, S.; Pérez-Stable, E.J.; Gregorich, S.E.; Livaudais-Toman, J.; Karliner, L.S., 2017: Hospital discharge preparedness for patients with limited English proficiency: A mixed methods study of bedside interpreter-phones. Assess effects of a bedside interpreter-phone intervention on hospital discharge preparedness among patients with limited English proficiency (LEP). Mixed-methods study compared patient-reported discharge preparedness and knowledge of medications...

Duzic, E.; Coupry, I.; Downing, S., 1992: Factors determining the specificity of signal transduction by guanine nucleotide-binding protein-coupled receptors. I. Coupling of a2-adrenergic receptor subtypes to distinct G-proteins. The Journal of Biological Chemistry 267: 44-51

Lambert, J., 1914: Echinides calloviens du plateau da Cesareda (Portugal). Comun Comissao de Serv geol Portugal, 9 69-76

Gulshan Kumari; Sarva Jit Singh; Kuldip Singh, 1992: Static deformation of two welded elastic half-spaces caused by a point dislocation source. Closed-form analytic expressions for the displacements and stresses due to a point displacement dislocation located at an arbitrary point of a two-phase medium consisting of two homogeneous, isotropic, perfectly elastic half-spaces in welded conta...

Anonymous, 2004: Symposium 5: Integrated Food Systems for Food Security in a Changing World Environment. Journal of Food Science 69(4): H130-CRH135