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Short-lived immunity against pertussis, age-specific routes of transmission, and the utility of a teenage booster vaccine

, : Short-lived immunity against pertussis, age-specific routes of transmission, and the utility of a teenage booster vaccine. Vaccine 30(3): 544-551

Pertussis incidence has been increasing for the past two decades in Norway, as in much of the highly vaccinated world. The greatest increase is in teenagers, although the most severe cases occur in infants. A teenage booster is recommended globally, largely with the aim of reducing infant incidence. However few countries have implemented the booster, and almost no data have been published on its utility in preventing infant cases. We aim to assess the duration of vaccine-induced immunity, and the possibility for a teenage-booster vaccine to protect infants in Norway. and findingsWe used a unique data set that merged case reports with a national vaccine registry from Norway, 1996 21, to assess age- and cohort-specific hazards of infection. We also developed and implemented a likelihood-based method for estimating the duration of immunity, taking into account age-contact data relevant for pertussis transmission. The risk of infection in thirteen-year olds increased nearly four-fold, however the hazard in infants did not significantly change. The seasonality of cases in pre-school-aged children differed from that of school-aged children. The introduction of a childhood booster vaccine provided indirect protection for unvaccinated members of the cohort, but little protection to neighboring cohorts. Additionally, we found evidence for increasingly rapid infection after three doses of vaccine, potentially caused by significant and heterogeneous loss of immunity. An estimated 15% of vaccinated individuals lost their immunity within five years after vaccination. Immunity induced by the acellular pertussis vaccine prevents both disease and transmission, but is short-lived and heterogeneous. The age-mixing patterns lead to little contact between teenagers and infants. Therefore, while a teenage booster vaccine campaign would likely provide strong protection for cohorts of teenagers, it would provide little protection for infants.Immunity against pertussis is relatively short-lived and heterogeneous. Vaccination prevents both disease and transmission. The age-mixing patterns lead to little contact between teenagers and infants. A teenage booster vaccine will not likely indirectly protect infants..


PMID: 22119924

DOI: 10.1016/j.vaccine.2011.11.065

Other references

Goodstein, D.B.; Himmelfarb, R., 1975: Allopurinol-induced mandibular neuropathy. Abbreviated case report. Oral Surgery, Oral Medicine, and Oral Pathology 40(1): 51-52

Dalekos, G.N.; Patsiaoura, K.; Zachou, K.; Makri, E.D.; Liaskos, C.; Stathakis, N., 2001: Primary biliary cirrhosis presented as eosinophilia in asymptomatic women with or without elevated alkaline phosphatase. Hepatology 34(4 Pt 2): 526A, October

Doe, P.; Bhat, B.; Menary, R., 1979: Preliminary studies of a low fuel, hop drying kiln for Himachal Pradesh, India. Food technology in Australia 31(7): 302

Maurer, Golo, 2008: Who cares? Males provide most parental care in a monogamous nesting cuckoo. Cuckoos hold a prominent position in the study of parental care, because they show the greatest variation of any bird family in the way they care for their offspring. Despite this, few data are available on cuckoos with biparental care even thoug...

Cardoso, L.; Miasso, A.Inocenti.; Galera, S.Aparecida.Frari.; Maia, B.Marques.; Esteves, R.Braga., 2012: Adherence level and knowledge about psychopharmacological treatment among patients discharged from psychiatric internment. This exploratory, descriptive and prospective study aimed to identify the degree of adherence to psychopharmacological treatment of patients who were discharged from psychiatric hospitalization and their knowledge about their prescription and diag...

Galderisi, M.; Capaldo, B.; Sidiropulos, M.; D'Errico, A.; Ferrara, L.; Turco, A.; Guarini, P.; Riccardi, G.; de Divitiis, O., 2007: Determinants of reduction of coronary flow reserve in patients with type 2 diabetes mellitus or arterial hypertension without angiographically determined epicardial coronary stenosis. Background: Coronary flow reserve (CFR) may be reduced even in the absence of coronary artery disease. We investigated the determinants of CFR impairment in Type 2 diabetes mellitus (DM2) and in arterial hypertension (HTN) without epicardial coron...

Neubacher, S.; Dojahn, C.M.; Arenz, C., 2013: A rapid assay for miRNA maturation by using unmodified pre-miRNA. Without labeling RNA: A new rapid assay for micro-RNA maturation was developed. The assay depends on the cleavage of unmodified pre-miRNAs and the subsequent amplification of the mature miRNA by rolling circle amplification (see accompanying schem...

Varandani P.T.; Nafz M.A.; Chandler M.L.; Falkner F., 1974: Inhibition of glutathione insulin transhydrogenase by insulin analogues relation to relative hormonal activity. Federation Proceedings 33(3 PART 1): 276

Buchholz S.R.; Montgomery E.B.Jr, 1988: Head restraint device for chronic recording of neural activity in the awake monkey. An adjustable, stainless steel, head restraining device and small screw-tightened skull clips are described which enable us to record single unit neuronal activity chronically from awake, behaving primates of various sizes. We have used this metho...

Parker, W.H., 1966: History of the theories on the cause and treatment of husk (parasitic bronchitis). Veterinary Record 79(3): 75-79