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Rimonabant for neurocognition in schizophrenia: a 16-week double blind randomized placebo controlled trial

, : Rimonabant for neurocognition in schizophrenia: a 16-week double blind randomized placebo controlled trial. Schizophrenia Research 134(2-3): 207-210

To examine the effect of rimonabant on neurocognitive impairments in people with schizophrenia. Participants entered a 16-week double-blind, placebo-controlled, randomized clinical trial. A neurocognitive battery was administered at baseline and end of study. In comparison to rimonabant (2 mg/day), placebo-treated participants exhibited a significant improvement on the Repeatable Battery for the Assessment of Neuropsychological Status total score. In contrast, rimonabant was associated with significant improvement on a probabilistic learning task. There were no other significant treatment effects. Rimonabant did not improve global cognitive functioning, but did improve a specific learning deficit based on response to positive feedback.


PMID: 22137462

DOI: 10.1016/j.schres.2011.11.009

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