+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Dimethoate accelerates the extinction of eyeblink conditioning in mice

, : Dimethoate accelerates the extinction of eyeblink conditioning in mice. Neurotoxicology 33(1): 105-110

In agriculture, organophosphates are frequently used as insecticides and pesticides. These compounds decrease acetylcholine esterase (AChE) activity, thereby provoking an accumulation of the neurotransmitter acetylcholine at synapses and resulting in the over-stimulation of acetylcholine receptors. Using trace paradigms, we investigated the effects of dimethoate, a widely used organophosphate insecticide, on the classical conditioning of eyelid responses, a hippocampal-dependent mouse model of associative learning. Mice were conditioned with a trace shock-SHOCK paradigm having first implanted stimulating electrodes in the supraorbitary nerve and recording electrodes in the ipsilateral orbicularis oculi muscle. When these mice were injected with dimethoate (5, 2, 5 mg/kg/day) they were capable of acquiring associative learning, and the latency and amplitude of their unconditioned eyelid responses were unaffected by administration of the pesticide. However, dimethoate administration led to the rapid extinction of conditioned responses, suggesting that this organophosphate accelerates the extinction of this form of associative learning. Analysis of the motor function of these mice using the rotarod performance test revealed that motor function and performance clearly deteriorated following dimethoate administration, with no improvements over the following 4 days. Together these findings indicate that dimethoate accelerates the extinction of acquired conditioned responses, affecting associative learning and memory, and it impairs motor function and performance in mice.Dimethoate does not impair associative learning at acute subletal intoxication Dimethoate accelerates extinction of eyelid conditionig Dimethoate deteriorates mice locomotor skills.


PMID: 22182529

DOI: 10.1016/j.neuro.2011.12.003

Other references

Lin, Y.; Guan, B.; Wu, Q., 2001: Treatment of thoracolumbar tuberculosis complicated with paraplegia. To explore characteristics of thoracolumbar tuberculosis complicated with paraplegia, relationship between efficacy and approach of operation, and to discuss indication and applicability of conservative treatment. Forty-eight cases with thoracolum...

Vignes, J.; Heland, M., 1995: Comportement alimentaire au cours du changement d'habitat lie a l'emergence chez le saumon Atlantique, Salmo salar L., et la truite commune, Salmo trutta L., en conditions semi-naturelles. Bulletin Francais de la Peche et de la Pisciculture 337-339: 207-214

Moore, D.R.; Smith, A.; Hager, K.M.; Waldon, R.; Esko, J.D.; Hajduk, S.L., 1995: Developmentally regulated sensitivity of Trypanosoma brucei brucei to the cytotoxic effects of human high-density lipoprotein. The bloodstream developmental stages of the protozoan parasite Trypanosoma brucei brucei are lysed by normal human serum. The cytotoxic factor is a minor sub-class of human high-density lipoprotein termed trypanosome lytic factor (TLF). T.b. bruce...

Min, C.; Wang, P.; Chen, C.; Deng, Y.; Lu, Y.; Ming, H.; Ning, T.; Zhou, Y.; Yang, G., 2008: All-optical switching in subwavelength metallic grating structure containing nonlinear optical materials. All-optical switching based on a subwavelength metallic grating structure containing nonlinear optical materials has been proposed and numerically investigated. Metal-dielectric composite material is used in the switching for its larger third-orde...

Morrow, D.; Qin, C.; Smith, R.; Safe, S., 2004: Aryl hydrocarbon receptor-mediated inhibition of LNCaP prostate cancer cell growth and hormone-induced transactivation. LNCaP prostate cancer cells express the aryl hydrocarbon receptor (AhR), and treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces CYP1A1 protein and an Ah-responsive reporter gene. Similar results were obtained with the selective AhR...

Gonzaalez-Garcaia, M.-Paz; Rodraiguez, D.; Nicolaas, C.; Nicolaas, G.; Lorenzo, O., 2006: A protein phosphatase 2A from Fagus sylvatica is regulated by GA subscript 3(B and okadaic acid in seeds and related to the transition from dormancy to germination. Several gibberellic acid (GA subscript 3(B)-induced cDNA fragments encoding putative serine/threonine protein phosphatase (PP) 2A catalytic subunits were obtained by means of differential reverse transcriptase-PCR approach. The full-length clone,...

Doohan, J.P.; Samuel, C.E., 1993: Biosynthesis of reovirus-specified polypeptides. Analysis of ribosome pausing during translation of reovirus S1 and S4 mRNAs in virus-infected and vector-transfected cells. The steady-state distribution of translating ribosomes on the reovirus s1 and s4 mRNAs was determined using a sensitive primer extension inhibition assay and cDNA clones of the reovirus S1 and S4 genes. Positions of significant ribosome pausing in...

Narin, I.; Soylak, M.; Dogan, M., 1998: Rubidium and strontinum levels of natural water samples from the Middle Anatolia region of Turkey. Rubidium and strontium contents of water samples collected from the Central Region of Anatolia have been determined by flame atomic emission spectrometry (FAES). The results found by FAES were compared with the results found by total reflection x-...

Anonymous, 1983: National forest inventory: Department of Lozere, 1979-1980. Foret privee: (154) 99-102

J.H.G.ldie; A.J.C.ldman; H.A.H.pkins; W.B.L.oney, 1984: Experimental and theoretical basis for the concept of alternating chemotherapy and radiotherapy. International Journal of Radiation Oncology*Biology*Physics 10(supp-S2): 148-149