geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Contribution of serotonergic transmission to the motor and cognitive effects of high-frequency stimulation of the subthalamic nucleus or levodopa in Parkinson's disease


, : Contribution of serotonergic transmission to the motor and cognitive effects of high-frequency stimulation of the subthalamic nucleus or levodopa in Parkinson's disease. Molecular Neurobiology 45(1): 173-185

Although they are effective at treating the motor impairments that are the core symptoms of Parkinson s disease, current treatments, namely l-3,4-dihydroxyphenylalanine (l-DOPA), the gold standard medication and high-frequency stimulation of the subthalamic nucleus (HFS-STN), can lead to cognitive and mood alterations. Many of these side effects, such as depression, anxiety and sleep disturbances, could be related to abnormal functioning of the serotonergic system, but much basic research remains to be done. Molecular studies in humans and animal models of the disease have reported diverse drastic changes to the serotonergic system. It has also been shown that the serotonergic system both plays a major role in the mechanism of action of the current therapies and is altered by the therapies. It has been reported that HFS-STN decreases serotonin release in several regions, mostly via inhibition of serotonergic neuron activity. The involvement of serotonergic neurons in l-DOPA treatment is even more significant. First, serotonergic neurons, able to convert exogenous l-DOPA to dopamine, are a major site to release dopamine throughout the brain. Second, the substitution of serotonin by newly synthesized dopamine in serotonin neurons leads to acute and chronic alteration of serotonin release and metabolism. Therefore, both therapeutic approaches, via distinct mechanisms, decrease serotonergic system activity and, rather than alleviating cognitive or mood disorders, tend to aggravate them. Molecular strategies targeting the serotonergic system are being developed and could be decisive in limiting l-DOPA-induced dyskinesia, as well as mood and cognitive symptoms produced by antiparkinsonian therapies.

US$19.90

PMID: 22222679

DOI: 10.1007/s12035-011-8230-0


Other references

Van Leeuwen, P.; Schiermeier, S.; Hailer, B.; Lange, S.; Geue, D.; Hatzmann, W.; Grönemeyer, D., 2008: Effect of prenatal antiarrhythmic treatment on cardiac function in a twin pregnancy. We present a case of supraventricular tachycardia affecting one fetus in a twin pregnancy. Before and after treatment with flecainide and cardioversion, we examined conduction times and heart rate variability (HRV) in both twins on the basis of ma...

Jerison, HJ., 1986: The perceptual worlds of dolphins. Unknown

Andrianov, V.L.; Savel'ev, V.I.; Bystryĭ, K.N., 1986: Use of demineralized bone matrix in children. Eighty five clinical observations of the authors have shown autotransplants demineralized in the solution of hydrochloric acid to possess pronounced osteoinductive properties. Their ability to induce osteogenesis was mostly pronounced in simultane...

Ninh Thi Phip; Nojima, H.; Tashiro, T., 2007: Effect of umbel order and umbellet position on the production and characteristics of seeds and on the development and growth of seedlings in Angelica acutiloba Kitagawa. A. acutiloba, Touki, is a medicinal plant belonging to the Apiaceae family. Flowering is characterized by a series of sequentially formed umbels producing seeds. The present study was carried out to analyze the effect of the umbel order and umbell...

Sun, G.; Fahima, T.K.rol, A.; Turpeinen, T.G.ama, A.R.nin, Y.; Nevo, E., 1997: Identification of molecular markers linked to the Yr15 stripe rust resistance gene of wheat originated in wild emmer wheat, Triticum dicoccoides. The Yr15 gene of wheat confers resistance to the stripe rust pathogen Puccinia striiformis West., which is one of the most devastating diseases of wheat throughout the world. In the present study, molecular markers flanking the Yr15 gene of wheat...

Chi, Y.; Zhou, J.; Venkatesh, S.K.; Huang, S.; Tian, Q.; Hennedige, T.; Liu, J., 2014: Computer-aided focal liver lesion detection. Our aim is to develop an automatic method which can detect diverse focal liver lesions (FLLs) in 3D CT volumes. A hybrid generative-discriminative framework is proposed. It first uses a generative model to describe non-lesion components and then i...

Onisovets, Vk, 1973: On the intensification of livestock production. Proizvodstvo Goviadiny na Promyshlennoi Osnove: -17

Lange, G., 1956: Drainage and aspiration drainage in biliary surgery. Zentralblatt für Chirurgie 81(45): 2321-2323

Kinoshita, K.; Honjo, T., 2000: Unique and unprecedented recombination mechanisms in class switching. Current Opinion in Immunology 12(2): 195-198

Sørensen, M.; Horsman, M.R.; Cumming, P.; Munk, O.Lajord.; Keiding, S., 2005: Effect of intratumoral heterogeneity in oxygenation status on FMISO PET, autoradiography, and electrode Po2 measurements in murine tumors. Purpose: To explore conflicting results obtained when tumor hypoxia is assessed with Eppendorf electrode Po-2. measurements and with positron emission tomography (PET) by use of [F-18]fluoromisonidazole (FMISO).Methods and Materials: We compared t...