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Identification of hydrophobic tags for the degradation of stabilized proteins


, : Identification of hydrophobic tags for the degradation of stabilized proteins. Chembiochem 13(4): 538-541

New HyTs are a knockout: We previously reported that labeling HaloTag proteins with low molecular weight hydrophobic tags (HyTs) leads to targeted degradation of HaloTag fusion proteins. In this report, we employed a chemical approach to extend this hydrophobic tagging methodology to highly stabilized proteins by synthesizing and evaluating a library of HyTs, which led to the identification of HyT36.

US$19.90

PMID: 22271667

DOI: 10.1002/cbic.201100793


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