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CGI-58/ABHD5-derived signaling lipids regulate systemic inflammation and insulin action


, : CGI-58/ABHD5-derived signaling lipids regulate systemic inflammation and insulin action. Diabetes 61(2): 355-363

Mutations of comparative gene identification 58 (CGI-58) in humans cause Chanarin-Dorfman syndrome, a rare autosomal recessive disease in which excess triacylglycerol (TAG) accumulates in multiple tissues. CGI-58 recently has been ascribed two distinct biochemical activities, including coactivation of adipose triglyceride lipase and acylation of lysophosphatidic acid (LPA). It is noteworthy that both the substrate (LPA) and the product (phosphatidic acid) of the LPA acyltransferase reaction are well-known signaling lipids. Therefore, we hypothesized that CGI-58 is involved in generating lipid mediators that regulate TAG metabolism and insulin sensitivity. Here, we show that CGI-58 is required for the generation of signaling lipids in response to inflammatory stimuli and that lipid second messengers generated by CGI-58 play a critical role in maintaining the balance between inflammation and insulin action. Furthermore, we show that CGI-58 is necessary for maximal TH1 cytokine signaling in the liver. This novel role for CGI-58 in cytokine signaling may explain why diminished CGI-58 expression causes severe hepatic lipid accumulation yet paradoxically improves hepatic insulin action. Collectively, these findings establish that CGI-58 provides a novel source of signaling lipids. These findings contribute insight into the basic mechanisms linking TH1 cytokine signaling to nutrient metabolism.

US$19.90

PMID: 22228714

DOI: 10.2337/db11-0994


Other references

Vogel, J.P.; Tuna, M.; Budak, H.; Huo, N.; Gu, Y.Q.; Steinwand, M.A., 2009: Development of SSR markers and analysis of diversity in Turkish populations of Brachypodium distachyon. Brachypodium distachyon (Brachypodium) is rapidly emerging as a powerful model system to facilitate research aimed at improving grass crops for grain, forage and energy production. To characterize the natural diversity of Brachypodium and provide...

Jacobs, C.; Goebel, R.; Sack, A.T., 2012: Visual awareness suppression by pre-stimulus brain stimulation; a neural effect. Transcranial magnetic stimulation (TMS) has established the functional relevance of early visual cortex (EVC) for visual awareness with great temporal specificity non-invasively in conscious human volunteers. Many studies have found a suppressive...

Downie J.; Howard R.; Bowcock B.; Cunningham A., 1989: Evaluation of hiv antibody testing strategy in a mixed low risk high risk population. Morisset, R A (Ed ) Ve Conference Internationale Sur Le Sida: Le Defi Scientifique Et Social; V International Conference on Aids: The Scientific And Social Challenge; Montreal, Quebec, Canada, June 4-9, 1262p International Development Research Centre: Ottawa, Ontario, Canada Illus Paper 377

Kociova, E.; Peter, V.; Mikulaj, L.; Hust'avova, H., 1969: The anti-stress effect of large amounts of chlortetracycline and zinc bacitracin for chickens. During fattening for 9 weeks chickens were exposed both to a long term stress of temperature between 36 degrees and 40 degrees C or to short term stress induced by giving Roakin, an antiplague vaccine. High temperature up to 5 weeks of age did not...

Malec, Pław.; Maleva, M.; Prasad, M.N.V.; Strzałka, K., 2009: Copper toxicity in leaves of Elodea canadensis Michx. Elodea canadensis (Canadian waterweed) has an ability to accumulate and bioconcentrate heavy metals. In this work, selected cellular responses for Cu treatment were studied in leaves of E. canadensis. Short term experiments, i.e. 1 week exposure t...

Bernard, O.; Hadj-Sadok, Z.; Dochain, D., 2001: Software sensors to monitor the dynamics of microbial communities: application to anaerobic digestion. A mass balance based model has been derived to represent the dynamical behavior of the ecosystem contained in an anaerobic digester. The model considers two bacterial populations: acidogenic and methanogenic bacteria. It forms the basis for the de...

Seaward, M.R.D.; Richardson, D.H.S., 1990: Atmospheric sources of metal pollution and effects on vegetation. Sources of atmospheric pollution are reviewed and include natural and agricultural sources, energy production, mining and smelting, secondary metal production and recycling operations, urban/industrial complexes and cars. The use of snow and ice,...

Korablev, M.V., 1961: The effect of sodium nucleate on the course and issue of leukopenia induced by tetrathione. Translated from Biull. Eksptl. Biol. i Med. 50(12): 58-61. 1960.Tetrathione introduced into the stomach of rabbits daily for 4 consecutive days, in a dose of 40 mg/kg, provokes a granulocytic type of leukopenia which fails to disappear spontaneous...

Ramsammy, L.S.; Kaloyanides, G.J., 1993: Mechanism of gentamicin inhibition of OK cell proliferation. Journal of the American Society of Nephrology 4(3): 757

Corr, E.M.; Cunningham, C.C.; Dunne, A., 2016: Cholesterol crystals activate Syk and PI3 kinase in human macrophages and dendritic cells. Cholesterol crystals are a key component of atherosclerotic lesions where they promote pro-inflammatory cytokine production and plaque destabilization. Antagonists of inflammatory mediators and agents that dissolve or prevent the formation of chol...