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Analysis of alcohol-based hand sanitizer delivery systems: efficacy of foam, gel, and wipes against influenza A (H1N1) virus on hands


, : Analysis of alcohol-based hand sanitizer delivery systems: efficacy of foam, gel, and wipes against influenza A (H1N1) virus on hands. American Journal of Infection Control 40(9): 806-809

Minimal research has been published evaluating the effectiveness of hand hygiene delivery systems (ie, rubs, foams, or wipes) at removing viruses from hands. The purposes of this study were to determine the effect of several alcohol-based hand sanitizers in removing influenza A (H1N1) virus, and to compare the effectiveness of foam, gel, and hand wipe products. Hands of 3 volunteers were inoculated with H1N1 and randomized to treatment with foam, gel, or hand wipe applied to half of each volunteer s finger pads. The log1count of each subject s treated and untreated finger pads were averaged. Log1reductions were calculated from these differences and averaged within treatment group. Between-treatment analysis compared changes from the untreated finger pads using analysis of covariance with treatment as a factor and the average log1untreated finger pads as the covariate. Log1counts on control finger pads were 2.7-5.3 log1of the 5% infectious dose for tissue culture (TCID5/.1 mL) (mean, 3.8 .5 log1TCID5/.1 mL), and treated finger pad counts for all test products were .5-1.9 log1TCID5/.1 mL (mean, .53 .17 log1TCID5/.1 mL). Treatments with all products resulted in a significant reduction in viral titers (>3 logs) at their respective exposure times that were statistically comparable. All 3 delivery systems (foam, gel, and wipe) produced significantly reduced viral counts on hands.

US$19.90

PMID: 22325728

DOI: 10.1016/j.ajic.2011.10.016


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