+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Lubricin Distribution in the Menisci and Labra of Human Osteoarthritic Joints

, : Lubricin Distribution in the Menisci and Labra of Human Osteoarthritic Joints. Cartilage 3(2): 165-172

Lubricin is the principal boundary lubricant on articular cartilage. We aimed to describe the distribution of lubricin in the other articulating structures in the human knee and hip-menisci and labra-and to relate this distribution to the degree of tissue degeneration. Eighteen menisci and 6 labra were obtained from patients with osteoarthritis undergoing total knee and total hip replacements, respectively. Macroscopically intact specimens were fixed in formalin and processed for H&E staining and immunohistochemical evaluation with an antilubricin monoclonal antibody. Lubricin was found in all tissues as a discrete layer on the tissue surface, within the extracellular matrix, and intracellularly, indicating that it plays a role in the tribology of these tissues in human subjects, and can be synthesized by cells within the tissues. While none of the samples displayed macroscopic tears, approximately 4% of the surface of the menisci and 8% of the surface of the labra displayed microscopic fibrillations and slight fraying. There was no effect of the degenerative changes on the distribution of lubricin. Lubricin coats nearly the entirety of the surfaces of menisci and labra, including microfibrillations and tears, with possible implications towards the tribology of the tissues and healing of tissue damage.


PMID: 26069629

DOI: 10.1177/1947603511429699

Other references

Hayasaka, S.; Goto, Y.; Maeda-Yamamoto, M., 2014: The effects of bathing in hot springs on the absorption of green tea catechin: a pilot study. Japan is a major tea producing country, and green tea is known for its health benefits which are believed to be due to catechins. However, difficulties in maintaining an adequate amount of catechins in the blood have been reported. Another importa...

Hargraves, J.Lee.; Hays, R.D.; Cleary, P.D., 2004: Psychometric properties of the Consumer Assessment of Health Plans Study (CAHPS) 2.0 adult core survey. To estimate the reliability and validity of survey measures used to evaluate health plans and providers from the consumer's perspective. Members (166,074) of 306 U.S. health plans obtained from the National CAHPS Benchmarking Database 2.0, a...

Piazza, G.A.; Thompson, W.J.; Pamukcu, R.; Alila, H.W.; Whitehead, C.M.; Liu, L.; Fetter, J.R.; Gresh, W.E.; Klein-Szanto, A.J.; Farnell, D.R.; Eto, I.; Grubbs, C.J., 2001: Exisulind, a novel proapoptotic drug, inhibits rat urinary bladder tumorigenesis. Exisulind (Aptosyn) is a novel antineoplastic drug being developed for the prevention and treatment of precancerous and malignant diseases. In colon tumor cells, the drug induces apoptosis by a mechanism involving cyclic GMP (cGMP) phosphodiestera...

Whittington, R.J.; Kearns, C.; Hyatt, A.D.; Hengstberger, S.; Rutzou, T., 1996: Spread of epizootic haematopoietic necrosis virus in redfin perch in southern Australia. Australian Veterinary Journal 73(3): 112-114

Sillanpää, M.; Lehtinen, T.; Paila, A.; Makhlin, Y.; Hakonen, P., 2006: Continuous-time monitoring of Landau-Zener interference in a cooper-pair box. Landau-Zener (LZ) tunneling can occur with a certain probability when crossing energy levels of a quantum two-level system are swept across the minimum energy separation. Here we present experimental evidence of quantum interference effects in sol...

Abhyankar, R.N., 1932: A suitable formula of Ringers solution for perfusion work on the hearts of Indian frogs. Defibrinated sheep's blood diluted 1:3 in ordinary or Bayliss' Ringer solution was found to increase the rate and range of beats in excised frog hearts. Glucose-containing solutions prolonged the survival period. No definite effect could...

Evans, H.E., 1954: The genus Psorthaspis on the Mexican central plateau (Hymenoptera, Pompilidae). American Museum Novitates, no. 1662: 1-18

Scheffel, J.W.; Setcavage, T.M.; Kim, Y.B., 1981: Induction of polyclonal immunoglobulin synthesis in porcine peripheral blood lymphocytes by pokeweek mitogen. Developmental and Comparative Immunology 5(2): 313-320

Simpson M.S., 1981: The effect of bleaching agents on tetracycline stained teeth. Annals of the Royal College of Surgeons of England 63(3): 208

Natochin, I.V.; Orbeli, L.A., 1992: Leon Abgarovich Orbeli in the '50s (pages from reminiscences). Fiziologicheskii Zhurnal SSSR Imeni I. M. Sechenova 78(11): 138-148