geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Caspase-1 level is higher in the scalp in androgenetic alopecia


, : Caspase-1 level is higher in the scalp in androgenetic alopecia. Dermatologic Surgery 38(7 Pt 1): 1033-1039

And objectivesInflammasomes that activate caspase-1 govern the innate immune inflammatory response. Whether hair loss associated with androgenetic alopecia (AGA) involves caspase-1 activation is not known. Immunohistochemical staining for caspase-1 was performed on scalp tissue sections, and protein lysates were analyzed from individuals with AGA (no treatment), and individuals with AGA taking finasteride with apparent hair growth, individuals with AGA taking finasteride without noted hair growth, and normal controls. In vitro studies of human keratinocytes were conducted to establish effects of finasteride, dihydrotestosterone (DHT), and testosterone on caspase-1 levels using immunoblot analysis. Caspase-1 is expressed in normal human adult epidermal keratinocytes. Caspase-1 expression is greater in men with AGA. In contrast, in men taking finasteride, caspase-1 levels were lower and were similar to those in normal controls. In vitro studies showed that keratinocytes treated with finasteride in combination with testosterone or DHT resulted in a significant decrease in caspase-1 expression. In vivo and in vitro finasteride treatment resulted in lower caspase-1 expression, supporting the idea that androgens influence innate immunity involved in the hair cycle in AGA. These findings may provide a basis for development of novel treatments for inflammatory skin and hair diseases.

US$19.90

PMID: 22404322

DOI: 10.1111/j.1524-4725.2012.02378.x


Other references

Kim, Y.R.; Kantor, J., 1998: Methods for the rapid analysis of the reticulocytes. Official Gazette of the United States Patent & Trademark Office Patents 1211(5): 5004, June 30

Ettinger I.L.; Kovaleva I.B.; Shul man N.V.; Przhegorlinskaya R.V., 1981: The change in heat sorption in a coal-methane system during various geologic processes. Doklady Akademii Nauk SSSR: 1, Pages 178-182. 1981.

Artas, H.; Gurbuzer, N., 2012: Inguinal hernia containing both ovaries and the uterus in an infant. Journal of Ultrasound in Medicine 31(7): 1138-1139

Hjort, Tage, 1996: Quantitative determination of IgG and IgA on sperm from infertile patients with and without antisperm antibodies. Immunoglobulins on patients sperm were determined by an ELISA technique, modified from the RIA described by Haas and D'Cruz (Am J Reprod Immunol, 1989; 20:37-43), i.e., suspensions of washed sperm (40, 20, 10, and 5 mill/ml) were added to a d...

Scholl, A.; Gent, M.; Daniel, H., 1995: Alanine transport across the human placental brush border membrane and the role of SH groups in carrier function. We have determined the kinetic characteristics of alanine transport into brush border membrane vesicles (BBMV) of human full term placenta and identified functional groups of the carrier proteins that are important for transport function. Alanine...

Lewis, T.L.; Workman, M., 1964: The effect of low temperature on phosphate esterification and cell membrane permeability in tomato fruit and cabbage leaf tissue. Exposure to 0[degree]C for 4 weeks caused a threefold increase in cell membrane permeability of mature-green tomato fruits (susceptible to chilling injury) but had no effect on that of cabbage leaves (not susceptible). While tomato fruits chilled...

Helion, J.G., 1996: If we build it, they will come. Creating an emotionally safe physical education environment. This article discusses how, by setting a few rules and encouraging students to follow them, a the atmosphere of physical education classes can be changed, and a safe, individualized learning environment created. Six guidelines which have been used...

Reyburn, B.; Li, M.; Metcalfe, D.B.; Kroll, N.J.; Alvord, J.; Wint, A.; Dahl, M.Janna.; Sun, J.; Dong, L.; Wang, Z-Ming.; Callaway, C.; McKnight, R.A.; Moyer-Mileur, L.; Yoder, B.A.; Null, D.M.; Lane, R.H.; Albertine, K.H., 2008: Nasal ventilation alters mesenchymal cell turnover and improves alveolarization in preterm lambs. Rationale: Bronchopulmonary dysplasia (BPD) is a frequent cause of morbidity in preterm infants that is characterized by prolonged need for ventilatory support in an intensive care environment. BPD is characterized histopathologically by persiste...

Waterlow, J.C., 1968: Observations on the mechanism of adaptation to low protein intakes. Lancet 2(7578): 1091-1097

Saha, S.; Salin, D.; Talon, L., 2014: Low Reynolds number suspension gravity currents. The extension of a gravity current in a lock-exchange problem, proceeds as square root of time in the viscous-buoyancy phase, where there is a balance between gravitational and viscous forces. In the presence of particles however, this scenario is...